The DTaP vaccination protects against three disease-causing bacteria. Diphtheria is an acute respiratory illness caused by Corynebacterium diphtheriae, and has a fatality rate of up to 20% among children under 5 years old. Tetanus, caused by Clostridium tetani toxin, is a spasmodic nervous system disorder. Bordetella pertussis causes an acute respiratory illness known as "whooping cough". The DTaP vaccine contains diphtheria and tetanus toxoids (inactivated toxins), and inactivated acellular pertussis to protect against these three infections. It is administered intramuscularly (IM). The 2nd of 5 total doses of DTap is recommended at 4 months of age. Contraindications to immunization include encephalopathy without an identifiable cause within 7 days of a previous dose, or progressive neurologic disease such as infantile spasms or uncontrolled epilepsy. Pertussis booster (Tdap) vaccine is now recommended during adolescence, regardless of immunization status and is also recommended even if the patient has already had pertussis.
Rotavirus is a naked, double-stranded, linear RNA virus in the Reoviridae family, that is the most common cause of severe diarrhea in infants and young children. The Rotavirus vaccination is a live-attenuated vaccine that is given orally. There are two available formulations; RV1 is a human assortment requiring 2 doses, and RV5 is a human-bovine assortment requiring 3 doses. Infants generally receive the 2nd dose of the rotavirus vaccine at their 4-month visit. If Rotarix was used, this is the last dose needed (the RotaTec preparation requires 3 doses).
Prior to development of the vaccination, Hib was the most common cause of bacterial meningitis in children. It also frequently caused other serious disease including epiglottitis, pneumonia, septic arthritis, and bacteremia. The Hib vaccine consists of the type B capsular polysaccharide conjugated to a carrier protein. This conjugation strengthens the T cell dependent response to vaccination. As the vaccination only covers type B, it does not offer any protection against other types or non-typable haemophilus. It is administered IM and the 2nd dose is given at the 4 month visit. If a 2 dose preparation was used (PedvaxHib or COMVAX), this is the last dose needed.
There are two polio vaccines - inactivated poliovirus vaccine (IPV) and live attenuated poliovirus vaccine (OPV) - although OPV is no longer used in the U.S. it is still used in many parts of the world. IPV induces active immunity against poliovirus types 1, 2, and 3. IPV is available alone and in combination with other pediatric vaccines. It is administered IM or subcutaneously, and the 2nd of 4 doses is given at 4 months of age. Any child up to 18 years of age should receive all doses, if behind. IPV is contraindicated in pregnancy or those with a pregnant female at home.
PCV is derived from a capsular polysaccharide, which allows for type-specific antibody killing. Polysaccharide vaccines were found to have poor efficacy in children <2 years old, however conjugation of the polysaccharide to immunogenic non-pneumococcal carrier proteins elicits a T cell-dependent memory response that is effective in infants. The Pneumococcal conjugate vaccine (PVC13) contains purified polysaccharides of 13 serotypes conjugated to a diphtheria protein. PCV13 is given in 4 doses, with the second being given at the 4-month visit. There must be a minimum of 4 weeks between the first 3 doses, and 8 weeks between the 3rd and last dose. The 23-valent pneumococcal polysaccharide vaccine (PS23) is given to provide additional protection to the PCV13 in some high-risk children (e.g. functional or anatomic asplenia) whom are >2 years old.
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