In contrast to live vaccines, in which the immune response closely resembles natural infection, the immune response to an inactivated vaccine is mostly humoral. Little or no cellular immunity results.
Inactivated vaccines always require multiple doses. In general, the first dose does not produce protective immunity, but “primes” the immune system. A protective immune response develops after the second or third dose. Antibody titers against inactivated antigens diminish with time. As a result, some inactivated vaccines may require periodic supplemental doses to increase, or “boost,” antibody titers.
There are two types of vaccines against poliomyelitis - Salk and Sabin. The Salk polio vaccine is a killed whole cell vaccine.
The rabies vaccine is a killed whole vaccine.
The cholera vaccine against Vibrio cholerae is a killed whole vaccine.
The hepatitis A vaccine is a killed whole vaccine.
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