Inactivated vaccines always require multiple doses. In general, the first dose does not produce protective immunity, but “primes” the immune system. A protective immune response develops after the second or third dose. Antibody titers against inactivated antigens diminish with time. As a result, some inactivated vaccines may require periodic supplemental doses to increase, or “boost,” antibody titers.
In contrast to live vaccines, in which the immune response closely resembles natural infection, the immune response to an inactivated vaccine is mostly humoral. Little or no cellular immunity results.
There are two types of vaccines against poliomyelitis - Salk and Sabin. The Salk polio vaccine is a killed whole cell vaccine.
In the 1880s, the rabies vaccine was developed and proved to be a spectacular success upon its first trial in a boy bitten by a rabid dog. The rabies vaccine is a killed vaccine
The cholera vaccine against Vibrio cholerae is a killed whole vaccine.
The hepatitis A vaccine is a killed whole vaccine.
Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.
*Average video play time: 2-3 minutes
Unforgettable characters with concise but impactful videos (2-4 min each)