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Killed (Inactivated) Whole Vaccines

Gravestone Vaccine-syringe in Hole-in-ground
tantheman
Killed (inactivated) whole vaccines are vaccines that have had their virulent capacity permanently removed, typically by heat or a chemical (e.g. formalin). They contain the whole organism against which immunity is desired (virus, bacteria). They mostly activate humoral immunity and do not have a risk of reverting to a virulent form. Since antibody levels decline over time with killed vaccines, patients require booster shots. Examples of killed whole vaccines include polio (Salk), hepatitis A, rabies, and cholera.
6 KEY FACTS
CHARACTERISTICS
Mostly Humoral Immune Response
Hummer and Moon

In contrast to live vaccines, in which the immune response closely resembles natural infection, the immune response to an inactivated vaccine is mostly humoral. Little or no cellular immunity results.

Require Booster Shots
Rocket-Boosters

Inactivated vaccines always require multiple doses. In general, the first dose does not produce protective immunity, but “primes” the immune system. A protective immune response develops after the second or third dose. Antibody titers against inactivated antigens diminish with time. As a result, some inactivated vaccines may require periodic supplemental doses to increase, or “boost,” antibody titers.

VACCINES
Polio (Salk)
Polo-player Socks

There are two types of vaccines against poliomyelitis - Salk and Sabin. The Salk polio vaccine is a killed whole cell vaccine.

Rabies
Rabid-Rabbit-Virus

The rabies vaccine is a killed whole vaccine.

Cholera
Collie-dog

The cholera vaccine against Vibrio cholerae is a killed whole vaccine.

Hepatitis A
Happy-Tie-Liver Apple

The hepatitis A vaccine is a killed whole vaccine.

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