Picornaviruses are non-enveloped, single-stranded positive sense RNA viruses with an icosahedral capsid. This virus family includes many important human pathogens, including enteroviruses and rhinoviruses. Enteroviruses that cause human disease include poliovirus, echovirus, coxsackievirus, and hepatitis A virus.
Coxsackievirus is a virus that belongs to the Picornaviridae family. These viruses are divided into group A and group B. In general, group A coxsackieviruses infect the skin and mucous membranes, causing febrile pharyngitis, hand foot and mouth disease, herpangina, and conjunctivitis.
A common presentation of infection by coxsackievirus is a nonspecific febrile illness and upper respiratory tract diseases, such as pharyngitis.
Hand, foot, and mouth disease is caused by infection of coxsackievirus A. Symptoms include fever, headache, and malaise, along with painful oral lesions and a body rash followed by sores and blisters on the palms of the hand and soles of the feet.
Coxsackievirus is the most common cause of aseptic meningitis, which is inflammation of the meninges without a pyogenic bacterial source. Both coxsackie A and B can lead to aseptic meningitis.
Aseptic meningitis caused by coxsackievirus is more common in the late summer months.
Coxsackievirus is a virus that belongs to the Picornaviridae family. These viruses are divided into group A and group B. Group B coxsackieviruses tend to infect the heart and the pleura as well as the pancreas.
Coxsackie B infection can lead to inflammation of the myocardium, leading to myocarditis.
Dilated cardiomyopathy is a condition that causes the heart to become weakened and enlarged, leading to the inability to pump blood efficiently. Coxsackievirus B can infect the heart causing weakening, leading to dilated cardiomyopathy.
Recently, the development of type 1 diabetes mellitus has been associated with previous coxsackievirus B infection.
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