Medicine (MD/DO)
Other Genetic Disorders
Bruton's Agammaglobulinemia

Master Bruton's Agammaglobulinemia with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Bruton's Agammaglobulinemia

Recommended Picmonics

picmonic thumbnail
Osteogenesis Imperfecta
picmonic thumbnail
Ehlers-Danlos Syndrome Disease
picmonic thumbnail
Ehlers-Danlos Syndrome Types
picmonic thumbnail
Marfan Syndrome
picmonic thumbnail
Thymic Aplasia (DiGeorge Syndrome)

Bruton's Agammaglobulinemia

Button-grandma Globulin-goblin
Bruton's agammaglobulinemia is a rare X-linked recessive immunodeficiency caused by an inability to generate mature B-cells. Mature B-cells are an essential component of the immune response as they normally manufacture immunoglobulins, which defend the body from infections. Bruton’s agammaglobulinemia is caused by a mutation in the BTK tyrosine kinase gene, which controls the differentiation of B-cells. Decreased immunoglobulins of all classes are observed. Because the disease is X-linked recessive, it is commonly seen in boys and presents as recurrent bacterial infections after 6 months of age. Infants typically do not get infections before 6 months because they have maternal IgG antibodies that protect them. The diagnosis can be suspected when patients have a normal amount of early B-cells (or pre-B cells) but decreased number of mature B-cells.
X-linked Recessive
X-suit with Recessive-chocolate

This disease is inherited in an X-linked recessive fashion, meaning this disease is more common in boys.

Defective Bruton Tyrosine Kinase
Broken Tire Kite-ace

Bruton tyrosine kinase, or BTK, normally controls the differentiation of immature B-cells to mature B-cells. This tyrosine kinase is defective in Bruton's agammaglobulinemia.

Blocks B Cell Maturation
Mature Basketballs Blocked

B-cell maturation is blocked due to dysfunction of Bruton tyrosine kinase, or BTK. This results in normal amounts of pre-B-cells (or immature B-cells), but decreased number of B-cells and decreased immunoglobulin production of all classes.

Decreased Immunoglobulins of All Classes
Down-arrow In-moon-goblins of all Classes

Defective B-cell maturation affects all classes of immunoglobulins, including IgG, IgM, IgE and IgA.

Bacterial Infections After Six Months
Bacteria-guy and (6) Sax

Infants with Bruton's agammaglobulinemia typically present with recurrent bacterial infections after 6 months of age due to poor immunoglobulin production. Infants typically do not get infections before six months because they have maternal IgG antibodies that protect them.

Maternal IgG Protects Before Six Months
(IgG) Gold-goblin wearing I-heart-mom-shirt Protecting Baby

Infants typically do not get infections before six months because they have maternal IgG antibodies that protect them.


Take the Bruton's Agammaglobulinemia Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Memorize facts with phonetic mnemonics

Ace Your Medicine (MD/DO) Classes & Exams with Picmonic:

Over 1,890,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medicine (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medicine (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medicine (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.