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DOWNLOAD PDFThis metabolic disorder is inherited in an autosomal recessive fashion.
Homogentisic acid oxidase is an enzyme that metabolizes homogentisic acid into 4-maleylacetoacetate.
This enzyme participates in the metabolism of tyrosine to fumarate.
Excessive amounts of homogentisic acid is harmful to cartilage, leading to severe and debilitating arthritis.
Excessive amounts of homogentisic acid is harmful to cartilage, leading to severe and debilitating arthritis.
Alkaptonuria can cause darkening of connective tissue in sun exposed areas and around sweat glands. This is because the accumulated homogentisic acid causes pigmented deposits in connective tissues throughout the body.
Urine can turn black if collected and left exposed to open air for a long period of time in alkaptonuria.
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