The atria, in response to stretching, release a peptide hormone called atrial natriuretic peptide (ANP), also known as ANH, and atriopeptin in response to high blood pressure.
ANP causes vasodilation in vascular smooth muscle by inhibiting the effects of catecholamines and elevating levels of cGMP.
ANP also antagonizes aldosterone by inhibiting renin secretion, which inhibits the renin-angiotensin-aldosterone system.
ANP increases the filtration rate of the glomerulus, which results in a greater excretion of sodium and water.
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