The humoral immunity process begins when a B cell binds to a free floating antigen in the lymph. B cells wait in the lymph node until antigen exposure.
The B cell presents the antigen to type II helper T cells, so that the helper T cells can stimulate the B cells into proliferation and antibody production.
Helper T cells express CD4 on the surface rather than CD8, which is expressed by killer T cells. The helper T cell binds to the presented antigen on the B cell receptor through the MHC-II complex. This causes cytokine release that stimulates the B cell to become active and produce antibodies specific to the presented antigen.
Plasma B cells are the active B cells that produce large amount of antibodies upon primary infection. They will eventually die, unlike memory cells which can last for the lifetime of an organism.
Memory B cells stay in the lymph nodes and wait to be re-exposed to the same antigen that previously infected the body. Upon exposure to that antigen, they proliferate rapidly and produce large amounts of antibodies for that antigen.
Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.START QUIZ NOW
Unforgettable characters with concise but impactful videos (2-4 min each)