Sertoli cells have FSH-receptors on their membranes and are activated by FSH (follicle-stimulating hormone). Sertoli cells nourish sperm and are sometimes referred to as "nurse cells."
Inhibin B is secreted by Sertoli cells and functions to inhibit FSH synthesis and secretion. Androgens and FSH stimulate inhibin B production. Production of Inhibin B in response to FSH constitutes a negative feedback loop.
Luteinizing hormone (LH) stimulates Leydig cells to produce testosterone. It does this through the upregulation of the enzyme cholesterol desmolase. LH shares the same alpha-subunit as TSH, FSH, and HCG. Limited cross reactivity between these hormones has been observed.
Leydig cells secrete testosterone in response to LH stimulation.
Testosterone stimulates the maturation of male sex organs at birth, and also plays a role in maintaining secondary sexual characteristics during and after puberty.
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