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First Aid for the USMLE Step 1 (2021)
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First Aid for the USMLE Step 1 (2021) | Physician Assistant (PA) School Study Aid

Page 258 -
9 Picmonics to Learn | 15 mins
Rituximab
Indications
Chronic Lymphocytic Leukemia (CLL)
Non-Hodgkin Lymphoma
Rheumatoid Arthritis
Microscopic Polyangiitis (MPA)
Granulomatosis with Polyangiitis (Formerly Wegener's)
Mechanism
Monoclonal Antibody Against CD20
Found on B Cell Neoplasms
Side Effects
Infusion Reactions
Skin and Mouth Reactions
Reactivation of Hepatitis B Virus (HBV)
Progressive Multifocal Leukoencephalopathy (PML)
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3 mins
Bevacizumab Mechanisms and Indications
Mechanisms
Monoclonal Antibody to VEGF
Inhibits Angiogenesis (and Vasculogenesis)
Indications
Capillaries Grow CORN (CG-CORN acronym)
Colorectal Cancer
Glioblastoma
Cervical Cancer
Ovarian Cancer
Renal Cell Carcinoma
Non-small Cell Lung Cancer (NSCLC)
Age-related Macular Degeneration
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2 mins
Bevacizumab Side Effects
Impaired (Delayed) Wound Healing
Hemorrhage
Nosebleed (Epistaxis)
GI Perforation
Thromboembolic Event
Osteonecrosis of the Jaw
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1 min
Hypercalcemia Treatments
Treat Underlying Disorder
Hydration
Dialysis
Calcium Restriction
Bisphosphonates
Calcitonin
Cinacalcet
Glucocorticosteroids
Denosumab
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2 mins
Celecoxib
Indications
Rheumatoid Arthritis
Osteoarthritis
Pain
Mechanism of Action
NSAID
Selectively Inhibits COX-2
Side Effects
Sulfa Allergy
Increased Risk of Thrombosis
GI Bleed
Contraindication
Pregnancy > 30 Weeks
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1 min
BRAF Inhibitors
Characteristics
BRAF Proto-oncogene
Serine/Threonine Kinase
V600E Mutation
Indications
Melanoma
Non-Hodgkin Lymphoma
Papillary Thyroid Carcinoma
Hairy Cell Leukemia
Drugs
Dabrafenib
Vemurafenib
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2 mins
Imatinib (Gleevec)
Indications
Chronic Myelogenous Leukemia (CML)
Inhibitor of BCR-ABL Tyrosine Kinase
Caused by Philadelphia Chromosome
GI Stromal Tumors
Inhibitor of C-kit Tyrosine Kinase
Toxicity
Fluid Retention
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1 min
TNF-Alpha Inhibitor Drugs and Complications
Etanercept
Decoy TNF- Alpha receptor
Anti-TNF- Alpha antibody
Adalimumab
Infliximab
Complications
Increased risk of infection
Predispose to Tuberculosis (TB) reactivation
Order Baseline PPD- skin test
Quantiferon Gold In-Tube
Order Chest X-Ray
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2 mins
Systemic Juvenile Idiopathic Arthritis Diagnosis and Management
Laboratory Findings
Increased Ferritin
Management
Glucocorticoids
Tocilizumab
Anakinra
Complications
Joint Deformities
Limb-Length Discrepancy
Uveitis
Macrophage Activation Syndrome
Considerations
Variable Prognosis
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2 mins

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