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First Aid for the USMLE Step 1 (2021)
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Page 193 -

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First Aid for the USMLE Step 1 (2021) | Physician Assistant (PA) School Study Aid

Page 193 -
4 Picmonics to Learn | 10 mins
Linezolid (Zyvox)
Mechanism Of Action
Oxazolidinone Antibiotic
Binds 23S rRNA of 50S Subunit
Inhibits Protein Synthesis
Indication
Gram-Positive Organisms
MRSA
VRE (Vancomycin Resistant Enterococci)
Side Effects
Bone Marrow Suppression
Decreased Platelet Count
Peripheral Neuropathy
Lactic Acidosis
Serotonin Syndrome
Considerations & Patient Education
Avoid Tyramine Containing Foods
picmonic thumbnail
4 mins
Macrolides
Bacteriostatic
Erythromycin
Azithromycin
Clarithromycin
Bind to 23S rRNA of 50S subunit
Inhibit protein synthesis by blocking translocation
Gram-Positive Cocci
Atypical pneumonia
Chlamydia
Resistance by methylation of 23S rRNA binding
picmonic thumbnail
1 min
Macrolides Side Effects
Side Effects
Diarrhea
Prolonged QT Interval
P450 Inhibitor
Cholestatic Hepatitis
Skin Rash
Eosinophilia
picmonic thumbnail
3 mins
Polymyxins
Mechanism of Action
Cationic
Act Like Detergents
Bind to Cell Membranes of Bacteria
Disrupt Their Osmotic Properties
Indications
Resistant Gram-Negative Infections
Side Effects
Neurotoxicity
Renal tubular necrosis
picmonic thumbnail
3 mins

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