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First Aid for the USMLE Step 1 (2021) | Physician Assistant (PA) School Study Aid
Cyanide Poisoning: Pathophysiology and Clinical Manifestation
- Pathophysiology
- Inhibits Complex IV of Oxidative Phosphorylation
- Forces Cells Into Anaerobic Metabolism
- Presentation
- Exposure to Fire Fumes
- Industrial Exposure
- Headache and Confusion
- Arrhythmias
- "Cherry Red" Skin
- Almond Breath/Taste
- Acute Renal Failure
4 mins
Cyanide Poisoning Diagnosis and Treatment
- Lab Findings
- Lactic Acidosis
- Elevated Venous PO2
- Check Carboxyhemoglobin
- Management
- Sodium Nitrate PLUS Sodium Thiosulfate
- Methemoglobinemia
- OR Hydroxocobalamin (First Line)
4 mins
Nitroprusside
- Mechanism of Action
- Direct Release of NO
- Increase cGMP
- Short Half-Life
- Indications
- Malignant Hypertension
- Side Effect
- Cyanide Toxicity
1 min
