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First Aid for the USMLE Step 1 (2021)
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Page 37 -

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First Aid for the USMLE Step 1 (2021) | Physician Assistant (PA) School Study Aid

Page 37 -
3 Picmonics to Learn | 4 mins
Rasburicase
Characteristics
Recombinant Uricase
Converts Uric Acid to Allantoin
Inidication
Hyperuricemia
Tumor Lysis Syndrome
Side Effects
Hypersensitivity Reaction
Methemoglobinemia
Considerations
Contraindicated in G6PD Deficiency
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1 min
Adenosine Deaminase Deficiency
Adenosine to Inosine
Excess ATP
Inhibition of Ribonucleotide Reductase
Prevents DNA Synthesis
Decreases B Cells and T Cells
Major cause of SCID
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1 min
Lesch-Nyhan Syndrome
X-linked Recessive
Absence of HGPRT
Hypoxanthine to IMP
Guanine to GMP
Excess uric acid
Gout
Retardation
Self-mutilation
Choreoathetosis
PRPP is increased
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2 mins

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