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Physician Assistant (PA)
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First Aid for the USMLE Step 1 (2019)
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First Aid for the USMLE Step 1 (2019) | Physician Assistant (PA) School Study Aid

Page 122 -
7 Picmonics to Learn | 12 mins
Bevacizumab Mechanisms and Indications
Mechanisms
Monoclonal Antibody to VEGF
Inhibits Angiogenesis (and Vasculogenesis)
Indications
Capillaries Grow CORN (CG-CORN acronym)
Colorectal Cancer
Glioblastoma
Cervical Cancer
Ovarian Cancer
Renal Cell Carcinoma
Non-small Cell Lung Cancer (NSCLC)
Age-related Macular Degeneration
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2 mins
Bevacizumab Side Effects
Impaired (Delayed) Wound Healing
Hemorrhage
Nosebleed (Epistaxis)
GI Perforation
Thromboembolic Event
Osteonecrosis of the Jaw
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1 min
Rituximab
Indications
Chronic Lymphocytic Leukemia (CLL)
Non-Hodgkin Lymphoma
Rheumatoid Arthritis
Microscopic Polyangiitis (MPA)
Granulomatosis with Polyangiitis (Formerly Wegener's)
Mechanism
Monoclonal Antibody Against CD20
Found on B Cell Neoplasms
Side Effects
Infusion Reactions
Skin and Mouth Reactions
Reactivation of Hepatitis B Virus (HBV)
Progressive Multifocal Leukoencephalopathy (PML)
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3 mins
Trastuzumab
Indications
HER-2+ Breast Cancer
Stomach Cancer
Mechanism
Monoclonal Antibody Against HER-2
Inhibition of Cellular Signaling
Cytotoxicity
Side effects
Cardiotoxicity
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1 min
TNF-Alpha Inhibitors Overview
Mechanism
Downregulates Pro-inflammatory Cytokines
Decreased Lymphocyte Activation and Migration
Granuloma Breakdown
Treats
Crohn's Disease
Rheumatoid Arthritis
Juvenile Rheumatoid Arthritis
Psoriasis
Ankylosing Spondylitis
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1 min
TNF-Alpha Inhibitor Drugs and Complications
Etanercept
Decoy TNF- Alpha receptor
Anti-TNF- Alpha antibody
Adalimumab
Infliximab
Complications
Increased risk of infection
Predispose to Tuberculosis (TB) reactivation
Order Baseline PPD- skin test
Quantiferon Gold In-Tube
Order Chest X-Ray
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2 mins
Abciximab and Tirofiban (GP IIb/IIIa Inhibitors)
Mechanism
IIb/IIIa Receptor Inhibitors
Inhibits Platelet Aggregation
Indications
Thrombotic Event Prevention
Acute Coronary Syndrome (ACS)
Percutaneous Coronary Intervention (PCI)
Side Effects
Bleeding
Considerations
Expensive
Combination Drug Therapy
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2 mins

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