Bevacizumab Mechanisms and Indications
- Monoclonal Antibody to VEGF
- Inhibits Angiogenesis (and Vasculogenesis)
- Capillaries Grow CORN (CG-CORN acronym)
- Colorectal Cancer
- Glioblastoma
- Cervical Cancer
- Ovarian Cancer
- Renal Cell Carcinoma
- Non-small Cell Lung Cancer (NSCLC)
- Age-related Macular Degeneration
Bevacizumab Side Effects
- Impaired (Delayed) Wound Healing
- Hemorrhage
- Nosebleed (Epistaxis)
- GI Perforation
- Thromboembolic Event
- Osteonecrosis of the Jaw
Rituximab
- Chronic Lymphocytic Leukemia (CLL)
- Non-Hodgkin Lymphoma
- Rheumatoid Arthritis
- Microscopic Polyangiitis (MPA)
- Granulomatosis with Polyangiitis (Formerly Wegener's)
- Monoclonal Antibody Against CD20
- Found on B Cell Neoplasms
- Infusion Reactions
- Skin and Mouth Reactions
- Reactivation of Hepatitis B Virus (HBV)
- Progressive Multifocal Leukoencephalopathy (PML)
Trastuzumab
- HER-2+ Breast Cancer
- Stomach Cancer
- Monoclonal Antibody Against HER-2
- Inhibition of Cellular Signaling
- Cytotoxicity
- Cardiotoxicity
TNF-Alpha Inhibitors Overview
- Downregulates Pro-inflammatory Cytokines
- Decreased Lymphocyte Activation and Migration
- Granuloma Breakdown
- Crohn's Disease
- Rheumatoid Arthritis
- Juvenile Rheumatoid Arthritis
- Psoriasis
- Ankylosing Spondylitis
TNF-Alpha Inhibitor Drugs and Complications
- Etanercept
- Decoy TNF- Alpha receptor
- Anti-TNF- Alpha antibody
- Adalimumab
- Infliximab
- Increased risk of infection
- Predispose to Tuberculosis (TB) reactivation
- Order Baseline PPD- skin test
- Quantiferon Gold In-Tube
- Order Chest X-Ray
Abciximab and Tirofiban (GP IIb/IIIa Inhibitors)
- IIb/IIIa Receptor Inhibitors
- Inhibits Platelet Aggregation
- Thrombotic Event Prevention
- Acute Coronary Syndrome (ACS)
- Percutaneous Coronary Intervention (PCI)
- Bleeding
- Expensive
- Combination Drug Therapy