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Pharmacist (Pharm.D)
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Inotropes

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Pharmacology | Pharmacist (Pharm.D) School Study Aid

Inotropes
7 Picmonics to Learn | 13 mins
Digoxin Mechanism and Indication
Direct inhibition of Na K ATPase
Indirect inhibition of Na Ca exchanger
Increase Ca in cell
Positive Inotropy
CHF
Stimulates Vagus Nerve
Decreased conduction at AV node
Atrial Fibrillation
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1 min
Acute Digoxin Toxicity
Clinical Symptoms
Hyperkalemia
Cholinergic (Nausea, Vomiting, Diarrhea)
Blurry Yellow Green Vision with Halo of Light
Arrhythmia
Bradycardia
EKG Changes
Prolonged PR interval
Decreased QT
Scooping on EKG
T Wave Inversion
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2 mins
Digoxin Toxicity Treatment
Activated Charcoal
Slowly Normalize K+
Digibind (Anti-Digoxin Fab)
Magnesium Sulfate
Lidocaine
Cardiac Pacing
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2 mins
Beta-1 Agonists
Dobutamine
Heart Failure
Cardiac Stress Test
Isoproterenol
Bradyarrhythmias
Torsades de Pointes
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58 secs
Dobutamine
Mechanism
Beta-1 Agonist
Inotropic
Indications
Heart Failure
Side Effects
Tachycardia
Arrhythmias
Considerations
Closely Monitor Patients
Other Meds May Increase Potency
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1 min
Milrinone and Amrinone
Mechanism of Action
Phosphodiesterase 3 Inhibitor
Potentiates Beta Receptor Effects
Inotrope
Vasodilator
Indication
Acute Decompensated Heart Failure
Side Effects
Ventricular Arrhythmias
Hypotension
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2 mins
Cilostazol and Dipyridamole
Mechanism of Action
Phosphodiesterase 3 Inhibitor (PDE-3)
Inhibits Platelet Aggregation
Vasodilation
Indications
Intermittent Claudication
Stroke Prevention
Coronary Stent Stenosis Prevention
Cardiac Stress Testing (Dipyridamole)
Side Effects
Flushing
Hypotension
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3 mins

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