Azathioprine (Imuran)
- Antimetabolite
- Prodrug of 6-mercaptopurine (6-MP)
- Inhibits Synthesis of Nucleic Acids
- Autoimmune Disorders
- Kidney Transplantation
- Myelosuppression
- Increased Toxicity with Allopurinol Use
- Pancreatitis
- Malignancy
Tacrolimus (Prograf) Overview
- Immunosuppressant
- Inhibits Calcineurin, Decreasing IL-2
- Transplant Rejection
- Atopic Dermatitis
- Increased Lymphoma Risk
- Avoid Grapefruit Juice
TNF-Alpha Inhibitor Drugs and Complications
- Etanercept
- Decoy TNF- Alpha receptor
- Anti-TNF- Alpha antibody
- Adalimumab
- Infliximab
- Increased risk of infection
- Predispose to Tuberculosis (TB) reactivation
- Order Baseline PPD- skin test
- Quantiferon Gold In-Tube
- Order Chest X-Ray
TNF-Alpha Inhibitors Overview
- Downregulates Pro-inflammatory Cytokines
- Decreased Lymphocyte Activation and Migration
- Granuloma Breakdown
- Crohn's Disease
- Rheumatoid Arthritis
- Juvenile Rheumatoid Arthritis
- Psoriasis
- Ankylosing Spondylitis
Hydroxychloroquine
- Immunosuppressant
- Malaria
- Rheumatoid Arthritis
- Systemic Lupus Erythematosus (SLE)
- Porphyria Cutanea Tarda
- Cardiotoxicity
- Retinopathy
- Ophthalmological Exams