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First Aid
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First Aid for the USMLE Step 1 (2023)
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First Aid for the USMLE Step 1 (2023) | Occupational Therapist (OT) School Study Aid

Page 35 -
3 Picmonics to Learn | 5 mins
Rasburicase
Characteristics
Recombinant Uricase
Converts Uric Acid to Allantoin
Inidication
Hyperuricemia
Tumor Lysis Syndrome
Side Effects
Hypersensitivity Reaction
Methemoglobinemia
Considerations
Contraindicated in G6PD Deficiency
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1 min
Adenosine Deaminase Deficiency
Adenosine to Inosine
Excess ATP
Inhibition of Ribonucleotide Reductase
Prevents DNA Synthesis
Decreases B Cells and T Cells
Major cause of SCID
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1 min
Lesch-Nyhan Syndrome
ETIOLOGY
X-linked Recessive
Pathophysiology
Absence of HGPRT
Hypoxanthine to IMP
Guanine to GMP
PRPP is Increased
Excess Uric Acid
Signs & Symptoms
Gout
Intellectual Disability
Self-mutilation
Choreoathetosis
Treatment
Allopurinol
Febuxostat
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3 mins

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Page 35 - in Biochemistry - First Aid for the USMLE Step 1 (2023) for Occupational Therapy