Master Second Generation Antihistamines with Picmonic for Nursing RN

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Second Generation Antihistamines

(2) Tutu Jeans Ant-tie-history-book
Jasmine_
Second generation antihistamines are indicated for allergic (allergic rhinitis). They are lipophobic molecules that work as histamine H1 receptor antagonists. An example is azelastine + fluticasone (Dymista), which is commonly administered as an intranasal spray instead of orally. Other examples include cetirizine (Zyrtec), loratadine (Claritin), and fexofenadine (Allegra). These drugs have fewer anticholinergic and CNS effects than their first generation counterparts.
10 KEY FACTS
INDICATIONS
Allergies
Allergy-alligator

Second generation antihistamines can be used as a monotherapy for mild allergic rhinitis symptoms including rhinorrhea, sneezing, urticaria, itching, and nasal congestion.

MECHANISM OF ACTION
Lipophobic
Lip-pho-bee

Second generation antihistamines are faster and longer acting (>24 hours) than first generation antihistamines. They are lipophobic, so they have fewer CNS effects.

Histamine H1 Receptor Antagonist
History-man with (1) Wand in Ant-toga

These drugs compete with histamine for H1 receptor sites. H1 receptors are found all over the body including on smooth muscle cells (in the respiratory tract and blood vessels), cardiomyocytes, and the central nervous system.

DRUGS
Azelastine + Fluticasone (Dymista)
Dime-Mister

Dymista is composed of azelastine, a second generation antihistamine, and a steroid called fluticasone. Patient education should include correct intranasal medication administration. Patients should prime the pump for first time use. Then shake the medication and blow their nose before administration. Medication applicator should be inserted about 1/4 or 1/2 an inch into the nostril. Patients should tilt their head when spraying the medication, and close the opposite nostril when administering. Patients should be sure to direct the medication away from their nasal septum.

Intranasal Spray
In-nose Sprayer

Some second generation antihistamines can be administered via intranasal spray. Dymista is commonly administered this way.

Cetirizine (Zyrtec)
Citrus-magazine

Cetirizine (brand name Zyrtec) is the most sedating of the second generation antihistamines.

Loratadine (Claritin)
Low-rationing

Loratadine (brand name Claritin) may be taken once or twice daily depending on severity of symptoms. Its peak action occurs 8 hours after administration.

Fexofenadine (Allegra)
Fox-fenced

Fexofenadine is the least sedating second generation antihistamine. High fat meals and fruit juice decrease the bioavailability of fexofenadine.

CONSIDERATIONS
Fewer Anticholinergic Effects
Down-arrow Fx Ant-tie-cola

Second generation antihistamines have fewer anticholinergic effects than first generation antihistamines. Anticholinergic effects include dry mouth or dry eyes. These drugs are also less sedating than their first generation counterparts.

Fewer CNS Effects
Down-arrow CNS-brain

Second generation antihistamines cause fewer CNS effects than first generation antihistamines since they are lipophobic. Patients often can take second generation antihistamines during the day since they are less sedating.

Unlock all 10 facts & definitions with Picmonic Free!

JOIN FREE

Take the Second Generation Antihistamines Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

START QUIZ NOW

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Nursing (RN) Classes & Exams with Picmonic:

Over 1,010,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Nursing (RN) student study app.

Picmonic for Nursing (RN) covers information that is relevant to your entire Nursing (RN) education. Whether you’re studying for your classes or getting ready to conquer your NCLEX®-RN, Hesi, ATI, TEAS test, Kaplan exams, we’re here to help.

Works better than traditional Nursing (RN) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.