Leukotrienes are inflammatory mediators, responsible for producing bronchoconstriction, inflammation, and airway edema in patients with asthma. Montelukast (Singulair) blocks the action of leukotriene receptors in the lungs and bronchial tubes, thereby reducing inflammation and bronchoconstriction.
This medication can be used to relieve nasal congestion in patients with seasonal allergies. Singulair is typically used for patients who do not respond to intranasal glucocorticoid or antihistamine therapy, due to the rare but serious side effects that can occur.
Montelukast (Singulair) can be used for prevention or maintenance therapy of asthma. This medication should not be used to treat asthma attacks, as it is not fast-acting.
Montelukast (Singulair) can be used to treat exercise induced bronchospasm; however, it is recommended that patients use a short-acting, beta-2 agonist medication instead.
Patients may experience a lack of energy or fatigue while taking montelukast (Singulair).
Headaches may occur in patients taking montelukast (Singulair); however, side effects are generally limited.
Changes in mood, such as depression, can occur when using this medication. Patients should be encouraged to report any changes in mood or behavior immediately.
Although rare, patients taking montelukast (Singulair) may experience suicidal thoughts or actions. Patients should be encouraged to report any changes in mood or behavior immediately.
Patients taking montelukast (Singulair) are at an increased risk of developing Churg-Strauss syndrome (eosinophilic granulomatosis with polyangiitis). Churg-Strauss syndrome is a potentially life-threatening autoimmune disorder that causes inflammation of the blood vessels. Excessive inflammation may lead to tissue death and destruction in the lungs. One of the common signs associated with the syndrome is asthma.
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