Master Pioglitazone (Thiazolidinediones) with Picmonic for Nursing RN

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Pioglitazone (Thiazolidinediones)

Pug-glitter
Picmonic
Pioglitazone stimulates receptors in the body to increase cellular response to insulin, thus decreasing insulin resistance. This medication is only effective in the presence of insulin and can only be used in patients with type II diabetes. Side effects of pioglitazone include upper respiratory infection, muscle pain, sinusitis, headache, and heart failure. Patients taking pioglitazone are at increased risk for bladder cancer, and women taking this medication are more prone to bone fractures. Liver enzymes should be routinely monitored while taking pioglitazone due to the risk of liver toxicity.
12 KEY FACTS
-glitazones Suffix
Glitter-zone

Drugs classified as thiazolidinediones can be recognized by the ending “-glitazone.” They are also referred to as TZDs.

MECHANISM
Binds PPAR-Gamma
Binding Pepper-Grandma

Thiazolidinediones act by binding and stimulating peroxisome proliferator-activated receptor gamma (PPAR gamma), a nuclear cell transcription regulator that increases cellular response to insulin, especially in peripheral tissues. This action, in turn, decreases insulin resistance in patients with type II diabetes.

Decreases Insulin Resistance
Down-arrow Insect-syringe Resistance swatter

Thiazolidinediones act by binding and stimulating peroxisome proliferator-activated receptor gamma (PPAR gamma), a nuclear cell transcription regulator that increases cellular response to insulin, especially in peripheral tissues. This action, in turn, decreases insulin resistance in patients with type II diabetes.

INDICATIONS
Type 2 Diabetes
Dyed-bead-pancreas in (2) Tutu

Pioglitazone is only effective in the presence of insulin and can only be used in patients with type II diabetes. In patients with type II diabetes, this medication increases uptake of glucose by skeletal muscle and fat cells, thus lowering blood sugar.

SIDE EFFECTS
Weight Gain
Up-arrow Scale

This medication classically causes an unwanted weight gain side effect in many patients.

Heart Failure
Dead Heart

Pioglitazone can lead to fluid retention, increasing a patient’s risk of developing heart failure. Patients should be educated about the signs and symptoms of heart failure, such as difficulty breathing, edema, weight gain, and fatigue. Patients with mild heart failure should use pioglitazone with caution, while those with severe heart failure should not take this medication.

Myalgia
Mayo-algae

Myalgia, or muscle pain can occur when taking this medication.

Hypoglycemia
Hippo-glue-bottle

Pioglitazone actually has a lower risk than other diabetes medications for developing hypoglycemia. However, when combined with other diabetes medications, the risk of hypoglycemia exponentially increases with this drug class, especially in patients receiving insulin therapy. Signs and symptoms of hypoglycemia include nausea, tachycardia, cold, clammy skin, sweating, tremors, and muscle weakness.

Upper Respiratory Infection
Upper Respiratory Tract Bacteria

Patients taking pioglitazone may develop an upper respiratory infection, sinusitis, or headache. Signs and symptoms of a URI include runny or stuffy nose, sneezing, sore throat, and a cough.

CONSIDERATIONS
Increased Risk of Bladder Cancer
Up-arrow Risk from Bladder Tumor-guy

Long-term use of pioglitazone can increase the risk of developing bladder cancer, especially if the patients was on a high dose. If patients experience pain when urinating or if they notice blood in their urine, they should contact their healthcare provider immediately. Patients with a history of bladder cancer should not take this medication.

Increased Fracture Risk in Women
Up-arrow Risk of Fractured Woman

Long-term use of pioglitazone has also been shown to increase the risk of bone fractures in women. Women taking this medication should participate in regular weight-bearing exercise and ensure adequate intake of calcium and vitamin D to prevent fractures.

Monitor Liver Enzymes
Monitor with Liver Enzymes

The drug troglitazone, also a thiazolidinedione, was taken off the market due to hepatotoxicity, thus, there is concern about liver toxicity in those taking pioglitazone. Patients taking pioglitazone should monitor their liver function by having their AST and ALT levels evaluated every 3 to 6 months. Signs and symptoms of injury to the liver include nausea, vomiting, loss of appetite, yellowing of the skin, and dark urine. The patient should be taught to contact their healthcare provider, if these symptoms develop.

Unlock all 12 facts & definitions with Picmonic Free!

JOIN FREE

Take the Pioglitazone (Thiazolidinediones) Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

START QUIZ NOW

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Nursing (RN) Classes & Exams with Picmonic:

Over 870,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Nursing (RN) student study app.

Picmonic for Nursing (RN) covers information that is relevant to your entire Nursing (RN) education. Whether you’re studying for your classes or getting ready to conquer your NCLEX®-RN, Hesi, ATI, TEAS test, Kaplan exams, we’re here to help.

Works better than traditional Nursing (RN) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.