The use of amphetamines leads to feelings of euphoria, increased energy, and sharpened mental alertness. CNS stimulants decrease fatigue and increase feelings of greater mental agility and muscular power. Snorting or oral ingestion of amphetamines causes a slower onset of euphoria while smoking or intravenous injection quickly leads to euphoria.
CNS stimulation caused by amphetamines may cause prolonged alertness leading to insomnia. The individual may experience difficulty falling asleep due to prolonged wakefulness.
Amphetamines potently release and prevent the reuptake of norepinephrine. Increased levels of norepinephrine binds to adrenergic receptors and causes pupillary dilation or mydriasis.
Amphetamines may cause a rise in body temperature related to increased motor activity. Amphetamines overdose may lead to hyperthermia. Diaphoresis or profuse sweating may be present.
Amphetamines may increase systolic and diastolic blood pressure resulting in hypertension.
Excessive CNS stimulation caused by amphetamines abuse leads to tachycardia, or palpitations. Cardiac arrhythmias may also occur.
Chronic use of amphetamines may result in paranoia and hypervigilance. Increased dopamine related to amphetamine abuse may cause hallucinations and misperceptions of reality.
Amphetamine abuse overstimulates the central nervous system and leads to feelings of anxiety and restlessness.
CNS stimulation caused by amphetamines abuse causes anorexia. The individual may experience decreased appetite leading to weight loss and malnutrition.
Amphetamine overdose may induce seizures. Benzodiazepines such as lorazepam may be administered to treat seizures.
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