Ibuprofen is considered a Nonsteroidal Antiinflammatory Drug and reduces inflammation, pain and fever. NSAIDs are effective in the management of mild or moderate pain.
Ibuprofen functions by inhibiting cyclooxygenase (COX), which is responsible for the production of pain and inflammation. By inhibiting COX, ibuprofen reduces inflammation and pain.
Ibuprofen is recommended for the relief of mild to moderate pain due to the inhibition of cyclooxygenase and its antiinflammatory properties.
This drug is also effective in reducing a fever.
NSAIDs are effective in reducing inflammation and are therefore indicated for numerous inflammatory conditions such as rheumatoid arthritis, cystic fibrosis, and osteoarthritis.
Ibuprofen is associated with the risk of developing GI ulcers due to its COX inhibitor properties. This property can inhibit platelet aggregation and increase the risk of bleeding.
Ibuprofen is metabolized in the kidneys and therefore may become nephrotoxic in high doses meaning it can be damaging to the kidneys.
Ibuprofen is not recommended in children less than 6 months of age because young children may develop a rash related to Stevens Johnsons syndrome.
Alcohol use should be avoided with ibuprofen because it may increase the risk of GI irritation and bleeding. Ibuprofen decreases platelet aggregation, which is further produced with alcohol use.
Ibuprofen carries a black box notice warning of potential thrombotic events. It's non-selective inhibition of the COX-1, COX-2 isoenzymes predisposes patients to these complications.
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