Pharmacotherapeutics for Advanced Nursing Practice, 1st. Ed., Demler & Rhoads, 2018 | Registered Nurse (RN) School Study Aid
Gastroesophageal Reflux Disease (GERD) Assessment
- Relaxed Lower Esophageal Sphincter
- Dyspepsia (Indigestion)
- Belching
- Nighttime Coughing
- Dysphagia
- Epigastric Pain
- Regurgitation
- Heartburn (Pyrosis)
- Globus
Dinoprostone and Misoprostol
- Prostaglandins
- Promote Cervical Ripening
- Prevent GI Ulcers
- Medical Abortion
- Fetal Distress
- Hyperstimulation of Uterus
- Vaginal Insertion
- Give Before Induction of Labor
Sucralfate (Carafate)
- Creates Protective Barrier
- GI Ulcers
- Constipation
- Require Acidic Environment
- Give on Empty Stomach
- Oral Suspension Available
- May Decrease Absorption of Other Meds
Helicobacter Pylori
- Gram-Negative
- Bacilli
- Curved
- Polar Flagellum
- Catalase-Positive
- Oxidase-Positive
- Gastric and Duodenal Ulcers
- Ammonia
- Neutral Environment
- Gastric Adenocarcinoma
- MALT lymphoma
- Serology IgG antibody
- Stool Antigen
- Urease Positive Breath Test
- Biopsy
- 2 ABX and PPI
Helicobacter pylori Associations
- Gastritis
- Peptic Ulcer Disease
- Stomach Cancer
Ampicillin and Amoxicillin
- Aminopenicillin
- Broad Spectrum Penicillin
- Gram-Positive and Some Gram-Negative Infections
- Rash
- Diarrhea
- No Effect Against Staph Aureus
- Often combined with Beta Lactamase Inhibitor
- Allergic Reaction
Macrolides
- Bacteriostatic
- Erythromycin
- Azithromycin
- Clarithromycin
- Bind to 23S rRNA of 50S subunit
- Inhibit protein synthesis by blocking translocation
- Gram-Positive Cocci
- Atypical pneumonia
- Chlamydia
- Resistance by methylation of 23S rRNA binding
Metronidazole
- Bactericidal
- Forms Free Radical Toxic Metabolites
- Damages DNA
- Giardia lamblia
- Entamoeba Histolytica
- Trichomonas
- Gardnerella
- Anaerobes
- Metallic taste
- Disulfiram like Reaction with Alcohol
Tetracyclines Overview
- End in "-cycline"
- Bacteriostatic
- Infectious Diseases
- Acne
- Periodontal Disease
- Avoid Milk, Antacids, Iron
- Sunlight Protection
Cimetidine and Famotidine (H2 Receptor Blockers)
- -tidine Suffix
- H2 Receptor Blocker
- Suppress Gastric Acid Secretion
- Pneumonia
- Anti-androgen Effects
- CNS Changes
Proton Pump Inhibitors (PPIs)
- "-prazole" Suffix
- Zollinger-Ellison Syndrome
- Gastritis
- Peptic Ulcer
- Gastroesophageal Reflux Disease (GERD)
- Inhibit H+/K+/ATPase
- Hip fracture
- Pneumonia