Medicine (MD/DO)
First Aid
First Aid for the USMLE Step 1 (2023)
Page 664 -
Primary Ovarian Insufficiency (Premature Ovarian Failure)

Master Primary Ovarian Insufficiency (Premature Ovarian Failure) with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Primary Ovarian Insufficiency (Premature Ovarian Failure)

Recommended Picmonics

picmonic thumbnail
Imperforate Hymen
picmonic thumbnail
Vaginal Cancer
picmonic thumbnail
Vaginal Cancer Subtypes

Primary Ovarian Insufficiency (Premature Ovarian Failure)

(1) Wand Ovary Insufficiency
Premature Ovarian Failure
Incubator and Ovaries with Fail-file

Primary ovarian insufficiency is also referred to as premature ovarian failure.

Before Forty (40) Years Old
(40) oz

Primary ovarian insufficiency should be suspected in patients with decreased sex hormone levels after puberty and under the age of 40.

Idiot Hat

Primary ovarian insufficiency can have a number of causes, one of which is idiopathic because the exact cause is not always known.

Turner Syndrome

Turner syndrome is a genetic cause of primary ovarian insufficiency. In Turner syndrome, there is a lack, or partial loss, of one of the X-chromosomes. Primary ovarian insufficiency can occur in turner syndrome because there is an accelerated loss of follicles in the ovaries that leads to dysgenesis of the ovaries. This loss occurs before or after puberty. Notably, these patients experience menopause before menarche.

Fragile X Syndrome
Fragile-box with X-chromosome

Fragile X syndrome is an X-linked dominant disease that consists of trinucleotide repeats CGG. This disease presents with features such as developmental delay, autism, large ears, and a long face. The risk of Fragile X patients developing primary ovarian insufficiency increases with the number of trinucleotide repeats present. When there are 50–200 CGG repeats, there is a chance of developing primary ovarian insufficiency.


Primary ovarian insufficiency can be caused by autoimmune disease. Autoimmunity frequently targets the ovary, which manifests as primary ovarian insufficiency.

Signs of Menopause

Primary ovarian insufficiency appears as menopausal symptoms due to a lack of sex hormone production, specifically a lack of estrogen. These signs include hot flashes, atrophy of the vagina, amenorrhoea, and sleep disturbances.

Decreased Estrogen
Down-arrow Easter-egg

The ovary produces a decreased level of estrogen. Low estrogen levels lead to typical menopausal symptoms.

Increased LH
Up-arrow Luge

There are increased levels of LH in patients with primary ovarian insufficiency. This increase occurs due to a lack of negative feedback from estrogen.

Increased FSH
Up-arrow Fish

There are increased levels of FSH in primary ovarian insufficiency. This increase is due to a lack of negative feedback from estrogen. Usually, FSH is higher than LH.


Take the Primary Ovarian Insufficiency (Premature Ovarian Failure) Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Memorize facts with phonetic mnemonics

Ace Your Medicine (MD/DO) Classes & Exams with Picmonic:

Over 1,880,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medicine (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medicine (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medicine (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.