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Medicine (MD/DO)
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First Aid
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First Aid for the USMLE Step 1 (2023)
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Page 510 -
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Mesolimbic Pathway (Dopaminergic)

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Mesolimbic Pathway (Dopaminergic)

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6 KEY FACTS
Dopamine Pathway
Doberman Pathway

The mesolimbic pathway is one of the four dopaminergic pathways involved in the release of dopamine.

LOCATION
Ventral Tegmental Area
Tiger-metal

The mesolimbic pathway begins in the ventral tegmental area of the midbrain.

Nucleus Accumbens
A-cummerbund

The mesolimbic pathway ends at the nucleus accumbens of the forebrain.

CHARACTERISTIC
Reward System
Reward Sign

The mesolimbic pathway is responsible for controlling the reward pathway of the brain. This pathway can involve feelings such as positive reinforcement and pleasure.

DEFECT
Positive Symptoms
Positive (+) Sign

If there is a defect or inhibition of the mesolimbic pathway, then this can lead to the positive symptoms seen in schizophrenia. These positive symptoms can include delusions, hallucinations, and disorganized speech.

Target by Antipsychotics
Target on Ant-tie-psychiatrist

The mesolimbic pathway is the main target of antipsychotic medications used in the treatment of schizophrenia.

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