Ace Your First Aid for the USMLE Step 1 (2023) Classes and Exams with Picmonic: #1 Visual Mnemonic Study Tool for Medicine (MD/DO) Students

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First Aid for the USMLE Step 1 (2023) | Medicine (MD/DO) School Study Aid

Cell Cycle Phases

G0 Phase

Growth Arrest

G1 Phase

G1 Check By Rb And p53

S Phase

DNA Mismatch Repair

DNA Synthesis

G2 Phase

G2 Check

M Phase

Mitosis And Cytokinesis

3 mins

Prophase

Nuclear Membrane Disintegrates

Centrioles Migrate

Spindle Apparatus Forms

Meiosis I starts Diploid

Homologous Chromosomes form Tetrads

Tetrads Cross Over

Meiosis II starts Haploid

Mitosis starts Diploid

Sister Chromatid Pairs Stay Separated

2 mins

Metaphase

Microtubules Extend from Centrioles' Spindles

Centromere

Kinetochore

Meiosis I Tetrads Aligned at Metaphase Plate

Meiosis II Sister Chromatids Aligned at Metaphase Plate

Mitosis Sister Chromatids Aligned at Metaphase Plate

57 secs

Anaphase

Spindle Microtubules from Centrioles Split Pairs

Meiosis I Tetrad Splits into Two Sister Chromatid Pairs

Meiosis II Sister Chromatid Pair Splits into Two Chromatids

Mitosis Sister Chromatid Pair Splits into Two Chromatids

1 min

Telophase

Cytokinesis Divides Cells

Meiosis I Cell Ends Haploid

Meiosis II Cell Ends Haploid

Mitosis Cell Ends Diploid

Chromosomes Decondense into Chromatin

Nuclear Membrane Reforms

1 min

Li-Fraumeni Syndrome

Autosomal Dominant

TP53 Mutation

Loss of Heterozygosity

Osteosarcoma

Breast Cancer

Brain Tumors

Leukemia/Lymphoma

Adrenocortical Carcinoma

Supportive Care

3 mins

Cell Types

Permanent

Remain in G0

Cardiac Muscle

RBCs

Neurons

Stable

G0 Enter G1 when Stimulated

Hepatocytes

Labile

Never Go to G0

Skin

Hair

Bone Marrow

Germ Cells

2 mins

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