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First Aid for the USMLE Step 1 (2019) | Medicine (MD/DO) School Study Aid
- Pathophysiology
- Hemosiderin Deposition
- Autosomal Recessive
- HLA-A3
- Secondary to Transfusion Therapy
- Increase Iron
- Increase Ferritin
- Increased Transferrin Saturation
- Signs and Symptoms
- Micronodular Cirrhosis
- Hepatocellular Carcinoma
- Diabetes
- Bronze Skin Coloring
- CHF
- Arthropathy
- Testicular Atrophy
- Impotence
- Secondary Hemostasis
- Intrinsic Pathway
- Partial Thromboplastin Time (PTT)
- Heparin
- Extrinsic Pathway
- Prothrombin Time (PT)
- Warfarin
- Common Pathway
- Thrombin
- Convert Fibrinogen to Fibrin
- Stabilizes the Platelet Plug
- Prothrombin Time (PT)
- 10-14 seconds
- Activated Partial Thromboplastin Time (PTT or aPTT)
- 25-35 seconds
- Sources
- Dark Green Leafy Vegetables
- Synthesized by Intestinal Flora
- Mechanism
- Activated by Epoxide Reductase
- Gamma Carboxylation of Glutamate
- Activation of Clotting Factors II, VII, IX, X, Protein C and S
- Considerations
- Deficiency with Broad Spectrum Antibiotics
- Neonatal Hemorrhage with Increased PT and aPTT
- Warfarin is a Vitamin K Antagonist
- Mechanism
- Synthesizes Clotting Factors II, VII, IX, X
- Indications
- Hypoprothrombinemia
- Newborn Prophylaxis
- Bleeding from Warfarin Overdose
- Side Effects
- Shock
- Kernicterus
- Cardiac Arrest
- Considerations
- Bile Salts required for Intestinal Absorption
- Increased Risks with IV Administration
- Clinical Features
- Bleeding
- Neonatal Hemorrhage with Increased PT and aPTT
- Etiologies
- Liver Disease
- Chronic Antibiotic Use
- Vitamin K Antagonists
- Malabsorption
- Dietary Deficiencies
- Diagnosis
- Normal Bleeding Time
- Increased PT and PTT
- Considerations
- Neonatal Vitamin K Injection
- Characteristics
- Autosomal Dominant
- Increased Thrombin and Factor X
- Heparin Resistance
- Hypercoagulability
- Diagnosis
- Family History
- Normal PT, PTT, and Bleeding Time
- Antithrombin-Heparin Cofactor Assay
- Management
- Factor Xa Inhibitors
- Direct Thrombin Inhibitors
- Low Molecular Weight Heparin
- Antithrombin Replacement
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