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Pathology | Medicine (MD/DO) School Study Aid
Paget Disease Of The Breast
- Clinical Manifestations
- Spreading Ulceration At Nipple/Areola
- Eczematous Or Vesicular Rash
- Pruritus
- Breast Mass
- Bloody Or Yellow Discharge
- Pathophysiology
- Associated With Underlying Ductal Adenocarcinoma
- Caused By Ductal Adenocarcinoma Cells Migrating To Surface
- Workup
- Biopsy
- Bilateral Mammogram
4 mins
Invasive Ductal Carcinoma of Breast
- Characteristics
- Most Common Breast Cancer
- Presentation
- Firm, Palpable Mass
- Nipple Retraction
- Histologic Findings
- Spiculated Margins
- Microcalcifications
- Stromal Glandular Cells
- Management
- Surgery
- Chemotherapy
- Radiation
2 mins
Ductal Carcinoma in Situ of Breast
- Characteristics
- Noninvasive Malignancy
- Terminal Duct Lobular Unit (TDLU)
- Microcalcifications
- Comedo Necrosis
- Comedocarcinoma
- High Grade
- Dystrophic Calcification
- Management
- Surgical Resection
- Considerations
- Progresses to Invasive Breast Cancer
2 mins
Fibrocystic Changes of Breast
- Characteristics
- Benign
- Premenopausal Women
- Presentation
- Bilateral, Multifocal Breast Pain
- Diagnosis
- Ultrasound
- Mammogram
- Biopsy
- Nonproliferative
- Sclerosing Adenosis
- Ductal Hyperplasia
- Management
- Observation
- Pharmacologic Interventions
- Surgery
3 mins
Inflammatory Carcinoma of Breast
- Characteristics
- Invasive Malignancy
- Invades Dermal Lymphatic Vessels
- Mimics Mastitis and Paget Disease of Breast
- Clinical Features
- Peau d'Orange
- Breast Tenderness
- Bloody Nipple Discharge
- Considerations
- Poor Prognosis
2 mins
Lobular Carcinoma in Situ of Breast
- Characteristics
- Noninvasive Malignancy
- Absent Microcalcifications
- Decreased E-Cadherin
- Often Asymptomatic
- Considerations
- Surveillance
- Chemotherapy
- Prophylactic Surgery
2 mins
Invasive Lobular Carcinoma of Breast
- Characteristics
- Multifocal and Bilateral
- Decreased E-Cadherin
- "Single File" Cells
- Presentation
- Often Asymptomatic
- Management
- Surgery
- Chemotherapy and Radiation
2 mins
Fibroadenoma
- Most Common Benign Breast Tumor
- Stromal Tumor
- Presentation
- Women under 40
- Small, firm mass
- Sharp Edges
- Increased tenderness and size with Estrogen
- Management
- Biopsy
1 min
Intraductal Papilloma
- Presentation
- Bloody nipple discharge
- Women 20-40 years old
- Mechanism
- Small tumor in lactiferous ducts
- Occurs Centrally
- Occurs Peripherally
- Increased malignancy
- Diagnosis
- Too Small to Palpate
- Galactogram biopsy
1 min
Phyllodes Tumor
- Presentation
- Common in 40's
- Large Palpable Mass
- Mechanism
- Benign
- Rarely Malignant
- Low-Grade Tumor
- Leaf-Like
- Stromal Tumor
- Treatment
- Wide Resection
2 mins
Breast Cancer Diagnosis
- Mammography
- Ultrasound
- MRI for High Risk Patients
- Confirmed with Biopsy
- Considerations
- Lymph Node Involvement
- Receptor Positivity
- Estrogen and Progesterone Receptors
- HER-2
2 mins
Breast Cancer Interventions
- Radiation or Chemotherapy
- Hormonal Therapy
- Tamoxifen
- Lumpectomy
- Mastectomy
- Avoid BP and Injections Affected Arm
- Hand Exercises
- Considerations
- Grief Related to Body Image
- Prosthetics
- Reconstruction
- Lymphedema
3 mins
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