Ace Your First Aid for the USMLE Step 1 2019 Classes and Exams with Picmonic: #1 Visual Mnemonic Study Tool for Medical (MD/DO) Students
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First Aid for the USMLE Step 1 2019 | Medical (MD/DO) School Study Aid
Bernard-Soulier Syndrome
- Mechanism
- Autosomal Recessive
- Deficiency of Glycoprotein Ib (GpIb) Receptor
- Symptoms
- Mucosal Membrane Bleeding
- Menorrhagia
- Easy Bruising
- Labs
- Large Platelets
- Increased Bleeding Time
- No Platelet Agglutination with Ristocetin
3 mins
Glanzmann Thrombasthenia
- Pathophysiology
- Autosomal Recessive or Acquired as an Autoimmune Disorder
- Deficiency of Glycoprotein IIb/IIIa (Gp IIb/IIIa) Receptor
- Defective Platelet-to-Platelet Aggregation
- Symptoms
- Mucous Membrane Bleeding (Gingival Bleeding)
- Easy Bruising
- Increased Bleeding Time
- Normal Platelet Count
- Considerations
- Avoid NSAIDs
2 mins
Thrombotic Thrombocytopenic Purpura (TTP)
- Inhibition or deficiency of ADAMTS 13
- vWF Multimers are not degraded
- Microthrombi (and Emboli)
- Symptoms
- FAT RN Pentad
- Fever
- Anemia
- Thrombocytopenia
- Renal Dysfunction
- Neurologic Abnormalities (Altered Mental status)
- Treatment
- Plasmapheresis
- Corticosteroids
- Splenectomy
2 mins
Immune Thrombocytopenic Purpura
- Features
- Most Common Cause of Thrombocytopenia
- IgG Against Platelet GPIIb/IIIa
- Acute: Children After Viral Infection or Immunization
- Chronic: Women of Childbearing Age
- Clinical Presentation
- Bleeding
- Petechiae
- Isolated Thrombocytopenia
- Diagnosis
- Increased Megakaryocytes on Bone Marrow Biopsy
- Diagnosis of Exclusion
- Management
- Corticosteroids
- IVIG
- Splenectomy in Refractory Cases
6 mins
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