Master Aprepitant with Picmonic for Medicine

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9 KEY FACTS

Aprepitant is a substance P antagonist. This drug blocks the interaction of substance P to bind neurokinin type 1 receptors. It will cause an antiemetic effect.

Aprepitant works by blocking substance P to bind neurokinin type 1 receptors.

Aprepitant is used as an antiemetic agent due to its action on the neurotransmitter substance P/NK1 receptor that contributes to the pathogenesis of chemotherapy-induced nausea and vomiting. It also can be used to prevent postoperative nausea and vomiting (PONV) in adults.

Aprepitant and steroids can be used as prophylaxis for delayed chemotherapy-induced nausea and vomiting. On the other hand, acute chemotherapy-induced nausea and vomiting are commonly treated with 5-HT3 antagonists and a corticosteroids. Nevertheless, aprepitant can be used on both conditions.

Fatigue is one of the most common side effects of Aprepitant.

Diarrhea is one of the most common side effects present from Aprepitant.

Constipation is the most common side effect in adult patients taking Aprepitant to prevent postoperative nausea and vomiting (PONV).

Headache can occur as a side effect of Aprepitant.

Anorexia is one of the most common side effects of Aprepitant.

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