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Medicine (MD/DO)
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USMLE Step 2
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Endocrinology
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Diabetes Mellitus
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Central Diabetes Insipidus

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Central Diabetes Insipidus

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Central Diabetes Insipidus

Dyed-bead-pancreas with Sippy-cup
Kim567
5 KEY FACTS
CHARACTERISTICS
ADH Deficiency
Broken Vase

Diabetes insipidus is a problem with vasopressin/ADH levels. For central diabetes insipidus, there is a deficiency in ADH because the posterior pituitary has a problem producing and releasing ADH.

Increased Serum and Urine Osmolality
Up-arrow Syrup and Urinal Ozzy-mole

This disorder has an increase in serum osmolality. While there is no change in urine osmolality when water is restricted, urine osmolality is more than 50% increased when desmopressin (an analog of anti-diuretic hormone) is given.

ETIOLOGIES
Mental Illness
Metal-mental Eels

Psychiatric disorders are associated with the development of central diabetes insipidus. Examples can include head injury, infection, schizophrenia, and obsessive-compulsive disorder.

Brain Injuries
Brain injured

Secondary causes of this disorder also include brain injuries, which can result from surgery, tumors, hypoxia, and infiltrative lesions.

TREATMENT
Desmopressin
Designated Driver Vase-present

Desmopressin is a synthetic ADH analog that can be administered as a treatment.

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