Adenocarcinoma of the Lung
- Most Common Lung Cancer
- Most Common in Nonsmokers
- Peripheral Location
- KRAS, EGFR, and ALK Mutations
- Glandular Pattern
- Often Stains with Mucin
- Presents with Hemoptysis
- Clubbing
- Surgical Resection
- Chemotherapy and Radiation
Squamous Cell Carcinoma of the Lung
- Strong Correlation with Smoking
- More Common in Men
- Central Location
- Cavitating Lesion Extending to Hilum
- PTHrP Causes Hypercalcemia
- Keratin Pearls
- Intercellular Bridges
- Surgical Resection (if Early Stage)
- Chemotherapy and Radiation (if Later Stage)
Small Cell (Oat Cell) Carcinoma
- Aggressively Malignant
- Strong Correlation with Smoking
- Central Location
- Amplification of myc Oncogenes
- Narrowing of Bronchial Airways
- Cushing's Syndrome
- Ectopic ACTH
- Syndrome Of Inappropriate Antidiuretic Hormone (SIADH)
- Lambert-Eaton Syndrome
- Kulchitsky Cells
- Neuron-Specific Enolase Positive
- Chromogranin A Positive
- Chemotherapy and Radiation
Large Cell Carcinoma
- Strong Correlation with Smoking
- Poor Prognosis
- Peripheral Lesions
- Gynecomastia
- Galactorrhea
- Anaplastic Cells
- Pleomorphic Giant Cells
- May Produce Beta hCG
- Diagnosis of Exclusion
- Surgical Resection
- Less Responsive to Chemotherapy and Radiation
Bronchial Carcinoid Tumor
- Excellent Prognosis
- Symptoms of Bronchial Obstruction
- Often Asymptomatic
- Carcinoid Syndrome
- Diarrhea
- Wheezing
- Flushing
- 5-HIAA in Urine
- Nests of Neuroendocrine Cells
- Chromogranin A Positive
- Surgical Resection
- Octreotide for Symptomatic Relief