😌
STRESS LESS SALE SAVE UP TO 25% TODAY
Medicine (MD/DO)
/
USMLE Step 1
/
Neurology, Ophthalmology & Otology
/
Other Nervous System Physiology
/
Nigrostriatal Pathway (Dopaminergic)

Master Nigrostriatal Pathway (Dopaminergic) with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

DOWNLOAD PDF
Nigrostriatal Pathway (Dopaminergic)

Recommended Picmonics

picmonic thumbnail
Tuberoinfundibular Pathway (Dopaminergic)
picmonic thumbnail
Motor Neuron Signs UMN and LMN
picmonic thumbnail
Somatic Reflex Arc
picmonic thumbnail
Mesocortical Pathway (Dopaminergic)
picmonic thumbnail
Mesolimbic Pathway (Dopaminergic)

Nigrostriatal Pathway (Dopaminergic)

Knight-striped-ribbon
sesanch1
7 KEY FACTS
Dopamine Pathway
Doberman Pathway

The nigrostriatal pathway is one of the four dopaminergic pathways involved in the release of dopamine.

LOCATION
Substantia Nigra
Substantial Knight

The nigrostriatal pathway begins at the substantia nigra of the midbrain.

Striatum
Striped-ribbon

The nigrostriatal pathway ends at the striatum, specifically involving the putamen and caudate nucleus of the basal ganglia.

CHARACTERISTIC
Motor Function
Motor

The nigrostriatal pathway is responsible for controlling the motor functioning of the body.

Direct Pathway
Direct-route

The nigrostriatal pathway involves the basal ganglia, which is responsible for both the direct and indirect pathways of movement. The direct (excitatory) pathway begins in the cortex and excites the striatum (D1 receptor). The striatum then inhibits the substantia nigra. Normally, the substantia nigra inhibits excitatory structures. However, if the substantia nigra is inhibited, the thalamus is free to send excitatory input to the motor cortex, which leads to increased movement. Thus, the overall input of the direct pathway is excitatory.

Indirect Pathway
Indirect-route

The nigrostriatal pathway involves the basal ganglia, which is responsible for both the direct and indirect pathways of movement.The first indirect (inhibitory) pathway begins in the cortex and excites the striatum. The striatum then inhibits the subthalamic nucleus, which sends excitatory signals to the substantia nigra. The substantia nigra is then free to inhibit the thalamus, an excitatory structure. With the thalamus inhibited, excitatory signals cannot be sent to the motor cortex, which leads to decreased movement. Thus, the overall input of the indirect pathway is inhibitory.However, the second pathway involves the striatum stimulating the substantia nigra, acting on D2 receptors, which then inhibits the subthalamic nucleus. The inhibition of the subthalamic nucleus then allows excitatory signals from the thalamus to proceed to the motor cortex, resulting in increased movement.

DEFECT
Extrapyramidal Symptoms
X-Pyramid

If there is a defect of the nigrostriatal pathway, it leads to the presentation of extrapyramidal symptoms. In the case of inhibition, this can involve a type of pseudoparkinsonism. If instead stimulated, this can involve chorea.

DOWNLOAD PDF

Take the Nigrostriatal Pathway (Dopaminergic) Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Memorize facts with phonetic mnemonics

Ace Your Medicine (MD/DO) Classes & Exams with Picmonic:

Over 1,890,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medicine (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medicine (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medicine (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.