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Medicine (MD/DO)
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USMLE Step 1
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Cardiology
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Antihypertensive Agents
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Aliskiren

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Aliskiren

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Aliskiren

Alice-crying
benjamintran2023
9 KEY FACTS
INDICATIONS
Hypertension
Hiker-BP

Aliskiren is indicated for the treatment of hypertension.

MECHANISM OF ACTION
Direct Renin Inhibitor
Wrench in Inhibiting-chains

Aliskiren works by directly blocking the action of renin, a hormone made by the kidneys. Renin participates in blood pressure regulation by converting angiotensinogen to angiotensin I, which is then converted to angiotensin II, a potent vasoconstrictor. Angiotensin II also stimulates the release of aldosterone, which helps the body retain sodium, thus increasing blood pressure.

SIDE EFFECTS
Hyperkalemia
Hiker-banana

Hyperkalemia is a side effect of aliskiren. Hyperkalemia occurs when there is an excess of potassium in the blood.

Decreased GFR
Down-arrow GFR-gopher

A decrease in glomerular filtration rate (GFR) is a side effect of aliskiren. GFR is a measure of at what rate the kidneys are filtering blood.

Hypotension
Hippo-BP

Hypotension is a side effect of aliskiren. Lightheadedness, dizziness, blurred vision, weakness, and nausea are all common symptoms of hypotension.

Angioedema
Angel-edamame

Angioedema, a condition that results in swelling beneath the skin, can be brought on by aliskiren.

CONTRAINDICATIONS
ACE Inhibitors
ACE with Inhibiting-chains and Caution-tape

Combining aliskiren and ACE inhibitors can increase the risk of serious side effects such as hyperkalemia, decreased GFR, hypotension, and angioedema.

ARBs
Angel-tennis Receptor Blockers Caution-tape

Combining aliskiren and angiotensin receptor blockers (ARBs) can increase the risk of serious side effects such as hyperkalemia, decreased GFR, hypotension, and angioedema.

Pregnancy
Pregnant-woman Caution-tape

Aliskiren use during pregnancy may decrease fetal renal function. Additionally, the drug increases fetal and neonatal morbidity and mortality.

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