Aliskiren is indicated for the treatment of hypertension.
Aliskiren works by directly blocking the action of renin, a hormone made by the kidneys. Renin participates in blood pressure regulation by converting angiotensinogen to angiotensin I, which is then converted to angiotensin II, a potent vasoconstrictor. Angiotensin II also stimulates the release of aldosterone, which helps the body retain sodium, thus increasing blood pressure.
Hyperkalemia is a side effect of aliskiren. Hyperkalemia occurs when there is an excess of potassium in the blood.
A decrease in glomerular filtration rate (GFR) is a side effect of aliskiren. GFR is a measure of at what rate the kidneys are filtering blood.
Hypotension is a side effect of aliskiren. Lightheadedness, dizziness, blurred vision, weakness, and nausea are all common symptoms of hypotension.
Angioedema, a condition that results in swelling beneath the skin, can be brought on by aliskiren.
Combining aliskiren and ACE inhibitors can increase the risk of serious side effects such as hyperkalemia, decreased GFR, hypotension, and angioedema.
Combining aliskiren and angiotensin receptor blockers (ARBs) can increase the risk of serious side effects such as hyperkalemia, decreased GFR, hypotension, and angioedema.
Aliskiren use during pregnancy may decrease fetal renal function. Additionally, the drug increases fetal and neonatal morbidity and mortality.
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