Type I Collagen is found in all dermal layers. In addition, Type III Collagen, can also be seen within the adventitial dermis (including the papillary and the peri-adnexal dermis).
Type I Collagen is the primary collagen that is found in the cornea.
Type I Collagen is found in over 90% of all types of collagen in the body. In addition to the Dermis and Cornea, Type I Collagen has been identified in Bone where it provides it with its tensile strength. Osteogenesis Imperfecta is a disorder that is associated with a Type I collagen mutation.
Type I Collagen is involved in wound repair. Here, it contributes to scar tissue, and it's the end product of wound healing.
Tendons are composed of multi-hierarchical structures, including fibers (primary bundles), fascicles (secondary boundless), and fibrils. It is made up primary of Type I Collagen (60–80%) and Elastin (2%).
Type II Collagen composes about 80% of total collagen found in the Vitreous Humor.
Cartilage is primarily made up of Type II Collagen.
The Nucleus pulposus is mainly formed from water (66%-86%) and Type II Collagen.
The Lymphatics are formed by Type III Collagen.
The Bone Marrow is formed by Type III Collagen.
Type III Collagen is found in granulation tissue and begin the process of early wound repair that is laid out by young fibroblasts. Don't forget, late wound repair is replaced with Type I Collagen.
Type III Collagen makes up blood vessels as well. A disorder that is associated with a Type III collagen mutation is the Vascular type of Ehlers-Danlos Syndrome. Mutations in COL3A1 result in faulty collagen synthesis results in patients with hyper-extending skin, hyper-mobile joints, and increased bleeding secondary vessels that are prone to rupture.
Type IV Collagen makes up basement membranes of various tissues. A disorder that is associated with Type IV Collagen mutation is Alport Syndrome. Here, mutations cause defective collagen synthesis, resulting in irregular thinning and thickening of the various basement membranes of tissues commonly seen in the glomerulus of the kidneys. Patient's maybe have Sensory blindness, deafness, and glomerulonephritis.
The lens is formed by Type IV Collagen. Alport syndrome is one of the collagen disorders that is impacted by a Type IV collagen defect. As noted above, patient can develop anterior lenticonus and posterior cataracts.
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