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First Aid for the USMLE Step 1 (2022)
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First Aid for the USMLE Step 1 (2022) | General Allied Health School Study Aid

Page 437 -
8 Picmonics to Learn | 16 mins
Burkitt's Lymphoma
Adolescents or young adults
C-myc gene moves next to heavy chain Ig gene
T 8;14
Starry sky appearance
Sheets of lymphocytes with interspersed macrophages
Jaw lesion in endemic (African) form
Pelvis or abdomen in non endemic form (American form)
Associated with EBV
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2 mins
Diffuse Large B Cell Lymphoma
Epidemiology
Most Common Non-Hodgkin’s Lymphoma
Usually in Older Adults
20% in Children
Features
May be Mature T Cell in Origin
Derives from Germinal Center
GI Tract and Brain
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2 mins
Follicular Lymphoma
Derives from Germinal Center
Occurs in adults
T14;18
BCL 2 overexpression
BCL 2 inhibits apoptosis
Indolent
Generalized lymphadenopathy
Bone marrow involvement
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2 mins
Mantle Cell Lymphoma
Older Males
Activation of Cyclin D Gene
T 11;14
CD5
Poor Prognosis
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55 secs
Helicobacter Pylori
Characteristics
Gram-Negative
Bacilli
Curved
Polar Flagellum
Catalase-Positive
Oxidase-Positive
Disease
Gastric and Duodenal Ulcers
Ammonia
Neutral Environment
Gastric Adenocarcinoma
MALT lymphoma
Diagnosis
Serology IgG antibody
Stool Antigen
Urease Positive Breath Test
Biopsy
Treatment
2 ABX and PPI
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2 mins
Adult T Cell Lymphoma
Caused by HTLV 1
Japan, West Africa, Caribbean
Present with cutaneous lesions
Aggressive
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1 min
Mycosis Fungoides / Sézary Syndrome
Mechanism
Neoplastic CD4+ Cells
Adults 40 - 60 Years Old
Mycosis Fungoides
Neoplastic CD4+ Cells Infiltrate Skin
Rashes Or Plaques
Pautrier's Abscesses
Sézary Syndrome
Neoplastic CD4+ Spread from Skin to Systemic Involvement
Sézary Cells With "Cerebriform Nuclei"
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2 mins
Antithrombin Deficiency
Characteristics
Autosomal Dominant
Increased Thrombin and Factor X
Heparin Resistance
Hypercoagulability
Diagnosis
Family History
Normal PT, PTT, and Bleeding Time
Antithrombin-Heparin Cofactor Assay
Management
Factor Xa Inhibitors
Direct Thrombin Inhibitors
Low Molecular Weight Heparin
Antithrombin Replacement
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3 mins

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