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Class11 CNS Depressants
Carbamazepine
Indications
First-line Seizure Medication
First Line for Trigeminal Neuralgia
Mechanism of Action
Stabilizes Inactive State of Na+ Channels
Side Effects
Stevens-Johnson Syndrome
Induce Cytochrome P450
Teratogen
Hepatotoxicity
Blood Dyscrasias
2 mins
Benztropine (Cogentin)
Mechanism
Anticholinergic
Indications
Parkinson's Disease
Acute Dystonia
Side Effects
Mydriasis
Dry Mouth
Urinary Retention
Tachycardia
Constipation
Psychosis
1 min
Parkinson's Drugs
Parkinsons Characteristics
Decreased Dopamine
Increased Acetylcholine
Drug Names
BALSA Acronym
Bromocriptine
Amantadine
Levodopa
Selegiline
Antimuscarinics
2 mins
Anticholinergics
B.O.AT.S Acronym
Benztropine
Parkinson's Disease
Oxybutynin
Decrease bladder spasms
Atropine
Mydriasis and Cycloplegia
Scopolamine
Motion Sickness
1 min
Parkinson's Disease Interventions
Medications
Levodopa/Carbidopa (Sinemet)
Entacapone (Comtan)
Selegiline (Eldepryl)
Amantadine (Symmetrel)
Bromocriptine (Parlodel)
Benztropine (Cogentin)
Considerations
Allow Extra Time
Ensure Patient Safety
Surgery As Last Resort
2 mins
Levodopa/Carbidopa (Sinemet)
Mechanism
Increases Dopamine in Brain
Indications
Parkinson's Disease
Side Effects
Nausea and Vomiting
Arrhythmias
Dyskinesia
Psychosis
Orthostatic Hypotension
Considerations
Report Uncontrolled Movements
Darkened Sweat or Urine
Off and On Phenomenon
2 mins
Seizure Precautions
Reduce Environmental Stimuli
Identify Triggers
Aura
Pad Side Rails
Bed Lowest Position
Oxygen and Suction Available
Consideration
Monitor Therapeutic Drug Levels
2 mins
Seizure Interventions
Maintain Airway
Side-lying Position
Support Head
Move to Floor
Benzodiazepines
Considerations
Never Restrain
No Objects in Mouth
Document Details
2 mins
Carbamazepine (Tegretol)
Mechanism
Inactivates Na+ Channels
Indications
Seizures
Bipolar Disorder
Trigeminal Neuralgia
Side Effects
Nystagmus
Ataxia
Hepatotoxicity
Blood Dyscrasias
Water Retention
Stevens-Johnson Syndrome
Considerations
Avoid Grapefruit Juice
2 mins
Phenobarbital (Barbiturates)
Mechanism
Barbiturate
Indications
Seizures
Side Effects
Ataxia
Paradoxical Excitement
Fatigue/Drowsiness
Considerations
Monitor Plasma Levels
High Potential for Abuse
1 min
Gabapentin
Primary Indication
Seizure Treatment
Secondary Indications
Peripheral Neuropathy
Postherpetic Neuralgia
Bipolar Disorder
Migraine Prophylaxis
Characteristics
Inhibits Voltage-Gated Ca2+ channels
Designed as a GABA Analog
Side Effects
Ataxia
Sedation
2 mins
Phenytoin
Indications
Status Epilepticus
Tonic-Clonic Seizures
Mechanism of Action
Blocks Na+ Channel Activation
Inhibition of Glutamate Release
Class IB Antiarrhythmic
Side Effects
Teratogenic
Macrocytic Megaloblastic Anemia
Induce Cytochrome P450
Drug-induced Lupus
Neuropathy
Hirsutism
Gingival Hyperplasia
1 min
Phenytoin (Dilantin)
Mechanism
Blocks Na+ Channels
Indications
Tonic-clonic Seizures
Side Effects
Ataxia
Nystagmus
Sedation
Gingival Hyperplasia
Purple Glove Syndrome
Hirsutism
Rash
Anemia
Considerations
Individualized Dosing
2 mins
Valproic Acid (Depakote)
Mechanism
Blocks Na+ Channels
Increases GABA Concentration
Indications
Tonic-clonic Seizures
Bipolar Disorder
Migraine Prophylaxis
Side Effects
Hepatotoxicity
Blood Dyscrasias
GI Distress
Tremor
Pancreatitis
1 min
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