Jack Shared "Heme/Onc Block" - 10 Picmonics
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Heme/Onc Block
Tumor Lysis Syndrome
- Characteristics
- Leukemia/Lymphoma Treatment
- Oncologic Emergency
- Clinical Features
- GI Distress
- Fatigue
- Arrhythmias
- Acute Kidney Injury
- Lab Findings
- Hyperkalemia
- Hyperphosphatemia
- Hyperuricemia
- Hypocalcemia
- Management
- Aggressive Hydration
- Electrolyte Correction
- Allopurinol
- Rasburicase
3 mins
Anemia Lab Values
- Iron Deficiency Anemia
- Serum Iron Decreased
- Transferrin Increased
- Ferritin Decreased
- % Transferrin Saturation Decreased
- Pregnancy and OCP Use
- Serum Iron Normal
- Transferrin Increased
- Ferritin Normal
- % Transferrin Saturation Decreased
- Anemia of Chronic Disease
- Serum Iron Decreased
- Transferrin Decreased
- Ferritin Increased
- % Transferrin Saturation Decreased or Normal
- Hemochromatosis
- Serum Iron Increased
- Transferrin Decreased
- Ferritin Increased
- % Transferrin Saturation Increased
3 mins
Fanconi Anemia
- Characteristics
- Autosomal Recessive
- Aplastic Anemia
- DNA Crosslink Repair Defect
- Clinical Presentation
- Short Stature
- Microcephaly
- Thumb and Forearm Malformations
- Cafe Au Lait Spots
- Ocular Abnormalities
- Horseshoe Kidney
- Lab Findings
- Chromosomal Breakage Testing
- Macrocytic Anemia
- Pancytopenia
- Management
- Monitor For Malignancy and Bone Marrow Failure
- Hematopoietic Stem Cell Transplantation
3 mins
ABO Hemolytic Disease of the Fetus and Newborn
- Characteristics
- ABO Incompatibilities
- Type O Mother and Type A/B Fetus
- Anti-A or Anti-B Antibodies
- Hemolytic Anemia
- Presentation
- Often Asymptomatic
- Neonatal Jaundice
- Diagnosis
- Negative Coombs Test
- Management
- Phototherapy
2 mins
Rh Hemolytic Disease of the Fetus and Newborn
- Characteristics
- Rh (Rhesus) Incompatibilities
- Rh(D)- Mother and Rh(D)+ Fetus
- Anti-Rh(D) Antibodies
- Hemolytic Anemia
- Presentation
- Hydrops Fetalis
- Neonatal Jaundice
- Kernicterus
- Diagnosis
- Positive Coombs Test
- Ultrasound
- Management
- RhoGAM [Anti-Rh(D) Immunoglobulin]
- Intrauterine Blood Transfusion
- Phototherapy
- IVIG (Intravenous Immunoglobulin)
4 mins
Diamond-Blackfan Anemia
- Characteristics
- Red Blood Cell Aplasia
- Macrocytic Anemia
- Clinical Features
- Short Stature
- Craniofacial Anomalies
- Triphalangeal Thumbs
- Diagnosis
- Increased HbF (Fetal Hemoglobin)
- Management
- RBC Transfusion
- Steroids
- Hematopoietic Stem Cell Transplantation
2 mins
Mycosis Fungoides / Sézary Syndrome
- Mechanism
- Neoplastic CD4+ Cells
- Adults 40 - 60 Years Old
- Mycosis Fungoides
- Neoplastic CD4+ Cells Infiltrate Skin
- Rashes Or Plaques
- Pautrier's Abscesses
- Sézary Syndrome
- Neoplastic CD4+ Spread from Skin to Systemic Involvement
- Sézary Cells With "Cerebriform Nuclei"
2 mins
Langerhans Cell Histiocytosis
- Characteristics
- Antigen Presentation Defect
- Lytic Bone Lesions
- Skull
- Presentation
- Hypopituitarism
- Diabetes Insipidus
- Skin Rash
- Recurrent Otitis Media
- Diagnosis
- Birbeck Granules
- "Tennis Racket" Appearance
- S100 Positive
- Management
- Observation
- Prednisone +/- Vinblastine
4 mins
Hemophagocytic Lymphohistiocytosis
- Characteristics
- Excessive Immune System Activation
- Cytotoxic T-cells and Macrophages
- Cytokine Storm
- Acquired or Sporadic
- Presentation
- Fever
- Hepatosplenomegaly
- Labs
- Increased Ferritin
- Pancytopenia
- Management
- Bone Marrow Transplantation
3 mins
Fanconi Anemia
- DNA repair defect in nonhomologous end joining
- Aplastic Anemia
- Short stature
- increased incidence of tumors/leukemia
- café-au-lait spots
- defective or absent thumbs
- Autosomal recessive
- More Common in Ashkenazi Jewish Population
- Microcephaly
- Microphthalmia
- Horseshoe Kidney
- Pancytopenia
- macrocytosis
- X-linked
- Hypogonadism
- large freckles
- strabismus (cross-eyed)
- Low-Set Ears
- Deafness
- pou
- pounding in ears (d/t hemorrhage or conduction defects or middle ear abnormalities)
- hematopoietic stem cell transplant to treat
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