Wayne Shared "T4 Module 1" - 256 Picmonics
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T4 Module 1
Alpha 1 Receptor
- Characteristics
- Gq Subunit
- Increase Vascular Smooth Muscle Contraction
- Increase Pupillary Dilator Muscle Contraction
- Increase Intestinal and Bladder Sphincter Muscle Contraction
1 min
Beta-2 Receptor
- Characteristics
- Gs Protein Class
- Cardiopulmonary
- Increased Heart Rate
- Increased Contractility
- Bronchodilation
- Metabolic
- Increased Lipolysis
- Increased Insulin
- Increased Glycogenolysis
- Increased Cellular Potassium Uptake
- Considerations
- Increased Aqueous Humor Production
- Vasodilation
- Decrease Uterine Tone
2 mins
Beta-1 Receptor
- Characteristics
- Gs Protein Class
- Increased Heart Rate
- Increased Contractility
- Increase Renin Release
- Increased Lipolysis
44 secs
Alpha 2 Receptor
- Characteristics
- Gi Subunit
- Decrease Sympathetic Outflow
- Decrease Insulin Release
- Decrease Lipolysis
- Increase Platelet Aggregation
- Decrease Aqueous Humor Production
2 mins
Neurotransmitters and Receptors of Autonomic NSystem
- Acetylcholine
- Muscarinic Receptors
- Norepinephrine
- Nicotinic Receptors
- Skeletal Muscles and Adrenal Medulla
- Renal Vascular Smooth Muscles
Direct Cholinomimetics
- Muscarinic Agonists
- Bethanechol
- Bladder and Bowels
- Methacholine
- Bronchoconstriction
- Pilocarpine
- Contracts Ciliary Muscle and Pupillary Sphincter
- Carbachol
- Releases Intraocular Pressure
1 min
Atropine
- Indications
- Blocks DUMBBeLSS
- Bradycardia
- Side Effects
- Skin Flushing
- Increased Temperature
- Dry Mouth
- Cycloplegia
- Disorientation
- Mydriasis
1 min
Nicotine
- Mechanism of Action
- Nicotine binds to a4b2 subunit of nACh receptor
- This causes influx of Na+ and Ca2+
- Ca2+ Binds to calmodulin
- Dopamine is released
- Also when N binds to nACh receptor: Ach, Epi, 5-HT, GABA, Endorphins and Glutamate are released (lots of good feelings...nicotine is very addictive!)
- Side Effects
- Insomnia
- Nausea
- Parital Agonist for Smoking Tx
- Varenicline
- Cytisine
- Chronic smoking leads to a decrease in MAO so on a regular basis will have increases in NE, ACh, 5-HT etc
1 min
Indirect Cholinomimetics
- Acetylcholinesterase Inhibitors
- Doesn't Cross BBB
- Edrophonium
- Myasthenia Gravis (Diagnosis)
- Pyridostigmine and Neostigmine
- Myasthenia Gravis (Tx)
- Ileus
- Crosses BBB
- Physostigmine
- Atropine Overdose
- Glaucoma
- Donepezil
- Alzheimer's
2 mins
Muscarinic Receptors
- Parasympathetic Nervous System
- M1
- Stimulates Gastric Acid Secretion
- M2
- Decreased Heart Rate
- Decreased Conduction Velocity
- M3
- Miosis
- Urination and Defecation
- Vasodilation
- Increased Secretions
- Bronchoconstriction
4 mins
Anticholinergics Continued
- Drugs
- Glycopyrrolate
- Reduces Airway Secretions
- Ulcer Treatment
- Ipratropium
- Asthma and C.O.P.D
- Dicyclomine
- Hyoscyamine
- Irritable Bowel Syndrome
1 min
Acetylcholinesterase Inhibitor Poisoning
- DUMBBELSS
- Diarrhea
- Urination
- Miosis
- Bronchospasm
- Bradycardia
- Emesis
- Lacrimation
- Salivation
- Sweating
2 mins
Anticholinergics
- B.O.AT.S Acronym
- Benztropine
- Parkinson's Disease
- Oxybutynin
- Decrease bladder spasms
- Atropine
- Mydriasis and Cycloplegia
- Scopolamine
- Motion Sickness
1 min
Pilocarpine (Pilocar)
- Mechanism
- Direct Cholinergic Agonist
- Contracts Iris Sphincter
- Contracts Ciliary Muscle
- Indications
- Xerostomia
- Glaucoma
- Side Effects
- Detached Retina
- Decreased Visual Acuity
- Eye Irritation
- Cholinergic Effects
- Considerations
- Avoid with Asthma or Bradycardia
2 mins
Donepezil
- Indications
- Alzheimer's Disease
- Mechanism of Action
- Acetylcholinesterase Inhibitor
- Increased Acetylcholine
- Side Effects
- Nausea and Vomiting
- Dizziness
52 secs
Succinylcholine
- Indications
- Inducing Paralysis
- Mechanism of Action
- Neuromuscular Blocking Drugs
- Motor Nicotinic Receptor
- ACh Receptor Agonist
- Depolarization
- Phases of Action
- Phase I (Paralysis Non-reversible)
- Phase II (Paralysis Reversible)
- Neostigmine (Reversal Agent)
2 mins
Malignant Hyperthermia
- Inheritance
- Autosomal-Dominant
- Pathophysiology and causes
- Ryanodine Receptor 1 Mutation
- Inhaled Anesthetics
- Succinylcholine
- Symptoms
- Autonomic Instability
- Muscle Rigidity
- Treatment
- Dantrolene
2 mins
Malignant Hyperthermia vs. Neuroleptic Malignant Syndrome vs. Serotonin Syndrome
- Autonomic Instability
- Muscle Rigidity
- Malignant Hyperthermia
- Ryanodine Receptor 1 Mutation
- Inhaled Anesthetics
- Succinylcholine
- Dantrolene
- Neuroleptic Malignant Syndrome
- Antidopaminergic Medications
- Hyporeflexia
- Myoglobinuria
- Dantrolene
- Serotonin Syndrome
- Serotonergic Medications
- Hyperreflexia
- Clonus
- Cyproheptadine
3 mins
Adrenergic Agonist (Trigger)
- Alpha 1 Receptor
- Alpha 2 Receptor
- Beta 1 Agonist
- Beta-2 Agonists
1 min
Nonselective Beta-Blockers
- "-olol" Suffix
- Nonselective
- Propranolol
- Timolol
- Nadolol
- Partial β Agonist
- Pindolol
- Nonselective β with α Blocking
- Carvedilol
- Labetalol
2 mins
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