Daniel Shared "Renal Part 1" - 28 Picmonics
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Renal Part 1
Urea Cycle
- Mitochondria
- N-Acetylglutamate
- Carbamoyl Phosphate Synthetase I
- NH3 + CO2
- Carbamoyl Phosphate
- Ornithine Transcarbamylase
- Citrulline
- Cytosol
- Aspartate
- Argininosuccinate
- Fumarate
- Arginine
- H2O to Urea
- Ornithine
3 mins
Renal Clearance
- Characteristics
- Estimates the Volume of Plasma Completely Cleared of a Substance by the Kidneys Per Unit Time
- Creatinine Clearance Used to Estimate GFR
- Equation
- Cx = (Ux * V) / Px
- Variables
- Urine Concentration of Substance X (Ux)
- Times Urine Flow Rate (V)
- Over Plasma Concentration of Substance X (Px)
3 mins
Filtration
- Filtration
- Glomerulus
- Creatinine Clearance
- Filtration Fraction
- Fractional Excretion
- Regulation
- Glomerular Filtration Rate
- Prostaglandins
- Renin Angiotensin Aldosterone System (RAAS)
- Tubuloglomerular Feedback
- Atrial Natriuretic Peptide
- Antidiuretic Hormone
- Norepinephrine
- Dopamine
3 mins
Renin Angiotensin Aldosterone System (RAAS) Regulators
- Activators
- Hypotension
- Hypovolemia
- Decreased NaCl Delivery to Macula Densa
- Sympathetic Stimuli
- Key Mediators
- Angiotensin II
- Aldosterone
- Antidiuretic Hormone
- Negative Feedback
- Atrial Natriuretic Peptide and Brain Natriuretic Peptide
2 mins
Angiotensin II Effects
- Effects On Vasculature
- Increases Vascular Smooth Muscle Contraction
- Increases Blood Pressure
- Effects on Kidney
- Efferent Arteriole Vasoconstriction
- Increases GFR
- Proximal Tubule
- Sodium and Water Reabsorption
- Adrenal Cortex
- Increases Aldosterone Secretion
- Effects on CNS
- Stimulates Posterior Pituitary Gland to Secrete Vasopressin (ADH)
- Stimulates Thirst in Hypothalamus
2 mins
Proximal Tubule
- Characteristics
- Na+ Reabsorbed Via Active Transport
- Water Follows Na+
- Most Of Glucose Reabsorbed
- Most Of Amino Acids Reabsorbed
- Bicarbonate Exchanged For H+
- Drugs and Toxins Excreted
- Filtrate Osmolarity Same As Plasma
- Leads To Loop Of Henle
2 mins
Loop of Henle
- Characteristics
- Descending Limb
- Water Follows Na+
- Medullary Hypertonicity
- Increased Water Reabsorption
- Vasa Recta
- Na+ Reabsorbed Via Active Transport
- Ascending Limb
- Reabsorbs Na+, K+, Cl-
- Decreased Concentration of Filtrate
- Impermeable to Water
- Distal Tubule
2 mins
Distal Tubule
- Characteristics
- Hormonally Regulated
- Aldosterone Causes Na+ Reabsorption
- Na+ Reabsorbed Via Active Transport
- Water follows Na+
- Early Distal Tubule is Impermeable to Water
- Parathyroid Hormone Causes Ca2+ Reabsorption
- Leads to Collecting Duct
2 mins
Collecting Duct
- Characteristics
- Na+ Reabsorption
- Vasopressin Causes Water reabsorption
- Concentrates Filtrate
2 mins
Gout Treatment
- Acute (Acute-angle)
- NSAIDs
- Glucocorticoids
- Colchicine
- Impairs Leukocyte Chemotaxis
- Chronic Gout (Crone Goat)
- Inhibit Xanthine Oxidase
- Allopurinol
- Febuxostat
- Inhibit Reabsorption of Uric Acid
- Probenecid
1 min
Ibuprofen (Advil, Motrin)
- Mechanisms
- NSAID
- COX Inhibitor
- Indications
- General Pain
- Fever
- Inflammatory Conditions
- Side Effects
- GI Ulcers
- Nephrotoxicity
- Rash
- Considerations
- Avoid with Alcohol
- Risk of Thrombotic Event
2 mins
Celecoxib
- Indications
- Rheumatoid Arthritis
- Osteoarthritis
- Pain
- Mechanism of Action
- NSAID
- Selectively Inhibits COX-2
- Side Effects
- Sulfa Allergy
- Increased Risk of Thrombosis
- GI Bleed
- Contraindication
- Pregnancy > 30 Weeks
1 min
Prednisone (Glucocorticoids)
- Mechanism
- Glucocorticoid
- Indications
- Inflammatory Conditions
- Organ Transplant Rejection
- Side Effects
- Cataracts and Glaucoma
- Cushing's Syndrome
- Osteoporosis
- Immunosuppression
- Hyperglycemia
- Ulcers
- Considerations
- Adrenal Insufficiency
- Taper Gradually
2 mins
Rasburicase
- Characteristics
- Recombinant Uricase
- Converts Uric Acid to Allantoin
- Inidication
- Hyperuricemia
- Tumor Lysis Syndrome
- Side Effects
- Hypersensitivity Reaction
- Methemoglobinemia
- Considerations
- Contraindicated in G6PD Deficiency
1 min
Loop Diuretics
- Mechanism of Action
- Thick Ascending Limb of Loop of Henle
- Inhibits Na+-K+-2Cl- Symporter
- Sulfa Drug
- Drug Names
- Furosemide
- Lasix
- Side Effects
- Gout
- Ototoxicity
- Hypocalcemia
- Hypokalemia
4 mins
Thiazide Diuretics
- Early Distal Tubule
- Inhibits Na/Cl Reabsorption
- Sulfa Drug
- Hyperglycemia
- Hyperlipidemia
- Hypercalcemia
- Hyperuricemia
- Hyponatremia
- Hypokalemic Metabolic Alkalosis
2 mins
Spironolactone (Aldactone)
- Mechanisms
- Inhibition of Aldosterone
- Potassium Retention
- Indications
- Hypertension
- Edema
- Heart Failure
- Side Effects
- Hyperkalemia
- Endocrine Effects
- Consideration
- Avoid Potassium Supplements
2 mins
Acetazolamide
- Indications
- Glaucoma
- Altitude Sickness
- Pseudotumor Cerebri
- CHF
- Metabolic Alkalosis
- Mechanism of Action
- Carbonic Anhydrase Inhibitor
- Sodium Bicarbonate (NaHCO3) Diuresis
- Side Effects
- Metabolic Acidosis
- Paresthesias
1 min
Mannitol (Osmitrol)
- Indications
- Increased Intracranial Pressure (ICP)
- Glaucoma
- Drug Overdose
- Mechanism of Action
- Osmotic diuretic
- Increased Urine Flow
- Side Effects
- Dehydration
- Contraindications
- Anuria
- CHF
2 mins
Desmopressin (DDAVP) and Vasopressin
- Indications
- Diabetes Insipidus
- Nocturnal enuresis
- Sepsis
- Cardiovascular Collapse
- Bleeding
- MOA
- Conserves water
- Adverse Reactions
- Severe hyponatremia
- Hypertension
- Angina
- Myocardial Infarction
- Nurse Implications
- Give before bed
- Monitor Electrolytes and Fluid
- Daily Weights And Monitor Is and Os
1 min
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