Mohammed Shared "Multiple Sclerosis" - 5 Picmonics
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Multiple Sclerosis
- Drug Therapy
- Corticosteroids
- Interferon Beta
- Dimethyl Fumarate (Tecfidera)
- Fingolimod (Gilenya)
- Mitoxantrone (Novantrone)
- Natalizumab (Tysabri)
- Considerations
- Increase Exercise
- Identify Triggers
- Cause/Mechanism
- Nerve Fiber Demyelination
- Assessment
- Motor Issues
- Cerebellar Signs
- Fatigue
- Paresthesias
- Spasticity
- Urinary Incontinence
- Optic Neuritis
- Considerations
- Women Between 20-50 Years Old
- Relapse and Remission of Symptoms
- Features
- More Common in Women
- Presents in 20's and 30's
- Northern Europeans
- Mechanism
- Unknown mechanism, genetic factor
- HLA-DRB1
- Autoimmune Demyelination of CNS
- White Matter of Brain and Spinal Cord
- T Cell Mediated Inflammation
- Symptoms
- Optic Neuritis
- Internuclear Ophthalmoplegia
- Scanning Speech
- Urinary and Fecal Incontinence
- Motor Issues (Intention Tremor, Paresis)
- Numbness and Pain
- Depression
- Relapsing Symptoms
- Diagnosis
- Gold Standard = Plaques on MRI
- Increased CSF Immunoglobulins (IgG)
- Oligoclonal Bands
- Step-wise Decline in Cognition
- 2nd Most Common Dementia
- History of Stroke
- Indirect Cholinomimetics
- Neurostimulants
- Antiplatelet Medication
- Multiple Lacunar Strokes
- Chronic White Matter Ischemia
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