Ryan Shared "Pharm Exam 8" - 78 Picmonics
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Pharm Exam 8
Amphotericin B
- Indications
- Systemic Mycosis
- Fungal Meningitis
- Last Resort for Protozoan infections
- Mechanism
- Polyene
- Binds Ergosterol
- Forms Membrane Pores
1 min
Amphotericin B Side Effects & Toxicity
- Side Effects
- Fever/Chills "Shake and Bake"
- Nephrotoxicity
- Milder with Liposomes
- Hypotension
- Anemia
- IV Phlebitis
- Arrhythmias
1 min
Cryptococcus neoformans
- Characteristics
- Monomorphic
- Encapsulated
- Polysaccharide Capsule
- Narrow-Based Buds
- Latex Agglutination
- Pigeons
- India Ink
- Mucicarmine stain
- Signs and Symptoms
- AIDS/Immunocompromised
- Meningitis
- Soap Bubble Lesions in Brain
- Pneumonia
- Treatment
- Fluconazole
- Flucytosine
- Amphotericin
3 mins
Flucytosine
- Indications
- Cryptococcus
- Candida
- Used in Combination with Amphotericin B or Azoles
- Mechanism
- Inhibits DNA and RNA Synthesis
- Converted to 5-FU by Cytosine Deaminase
- Side Effects
- Bone Marrow Suppression
1 min
Echinocandins
- "-Fungin" Suffix
- Indications
- Invasive Aspergillosis
- Candida
- Mechanism
- Inhibits Cell Wall Synthesis
- Inhibits Synthesis of Beta-glucan
- Side Effects
- GI Distress
- Flushing
1 min
Azoles (Ketoconazole)
- "-azole" suffix
- Indications
- Local and Less Serious Systemic Mycosis
- Mechanism
- Inhibits Ergosterol Synthesis
- Inhibits P450
- Side Effects
- Liver Dysfunction
- Inhibition of Testosterone Synthesis
1 min
Griseofulvin
- Mechanism
- Disrupts Microtubules in Mitosis
- Indications
- Antifungal for Superficial Infections
- Tinea and Ringworm
- Side Effects
- Teratogen
- P450 Inducer
- Confusion
- Headache
2 mins
Terbinafine
- Indications
- Dermatophytosis
- Onychomycosis
- Mechanism
- Inhibits Squalene Epoxidase
- Side Effects
- Hepatotoxicity
- GI Distress
- Taste Disturbances
- Headache
2 mins
Nystatin
- Indications
- Candidiasis
- Vaginal
- Oral
- Cutaneous
- Mechanism
- Polyene
- Binds Ergosterol
- Forms Membrane Pores
- Topical form of Amphotericin B
- Side Effects
- Rash
1 min
Plasmodium General
- Characteristics
- Protozoa
- Malaria
- Anopheles Mosquito
- Signs and Symptoms
- Cyclic Fever
- Headache
- Anemia
- Splenomegaly
- Diagnosis
- Blood Smear
- Treatment
- Chloroquine
- Mefloquine for Resistant Types
3 mins
Plasmodium Specific
- Malariae
- Fever Every Three Days
- Vivax/Ovale
- Fever Every Two Days
- Duffy Antigen Binding Site
- Duffy often absent in Black Population
- Primaquine treats dormant form in liver
- Falciparum
- Most severe
- Irregular Cycles
- Occludes capillaries in the brain, kidneys, and lungs
4 mins
Class IA Antiarrhythmics (Na+ Channel Blockers)
- Indications
- Arrhythmias
- Mechanism of Action
- Increase AP, ERP, and QT interval.
- Drugs
- Disopyramide
- Procainamide
- Drug-induced Lupus
- Quinidine
- Cinchonism
- Shared Side Effects
- Thrombocytopenia
- Torsades de Pointes
1 min
Tetracycline Mechanism
- Binds to 30 S to Prevent Attachment of Aminoacyl tRNA
- Limited CNS Penetration
- Divalent Cations Inhibit Absorption
- Must Not Take with Milk, Antacids, Iron
1 min
Tetracycline Drug Names and Indications
- Drug Names
- Demeclocycline
- Minocycline
- Doxycycline
- Fecally Eliminated
- Can be Used in Renal Failure
- Indications
- Antidiuretic Hormone Antagonist
- Chlamydia
- Rickettsia
- Borrelia burgdorferi
- Helicobacter Pylori
- Mycoplasma Pneumonia
3 mins
Tetracycline Toxicities
- Inhibition of Bone Growth in Children
- Teratogen
- Discoloration of Teeth
- Photosensitivity
- GI Distress
2 mins
Sulfonamides Mechanisms
- Bacteriostatic
- Gram-Positive
- Gram-Negative
- Nocardia
- Chlamydia
- PABA antimetabolites
- Inhibit dihydropteroate synthase
- Sulfamethoxazole
- Sulfisoxazole
- Sulfadiazine
1 min
Sulfonamides Side Effects
- Side Effects
- Hypersensitivity
- Nephrotoxicity
- Photosensitivity
- Kernicterus in Infants
- Displaces Warfarin from Albumin
- Considerations
- Hemolysis with G6PD Deficiency
3 mins
Entamoeba histolytica
- Pathophysiology
- Protozoa
- Amebiasis
- Ingestion of Cysts in Food and Water
- Signs and Symptoms
- Bloody Diarrhea
- Flask-Shaped Ulcer
- Liver Abscess
- Anchovy Paste
- RUQ Pain
- Diagnosis
- RBCs in Cytoplasm of Trophozoite
- Cyst With Four Nuclei
- Treatment
- Metronidazole
- Iodoquinol
3 mins
Giardia lamblia
- Characteristics
- Protozoa
- Ingestion of Cysts
- Seen in Campers
- Daycare Centers
- Mental Hospitals
- Infects Small Intestine
- Signs and Symptoms
- Bloating
- Flatulence
- Fatty Diarrhea
- Diagnosis
- Crescent-shaped Protozoa Adjacent to Epithelial Brush Border
- Predisposed if Low IgA
- Treatment
- Metronidazole
3 mins
Trichomonas vaginalis
- Characteristics
- Protozoa
- Signs and Symptoms
- Vaginitis
- Pruritus
- Foul-smelling Greenish Frothy Discharge
- Strawberry Cervix
- Diagnosis
- Corkscrew Motility on Wet Prep
- Treatment
- Metronidazole
2 mins
