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2.4 FA Heme/Onc
Whole Blood Composition
Electrolytes And Other Solutes
White Blood Cells (WBC)
Red Blood Cells (RBC)
Types of Blood Products
Packed Red Blood Cells
Fresh Frozen Plasma
Use within 24 Hours
Washing Removes Antibodies
Irradiation Destroys WBCs
Endothelial Cells are Damaged
Platelets Respond to Exposed Collagen and Stick
Platelets Release Recruiting Factors
More Platelets are Attracted
Soluble Fibrinogen Turns to Insoluble Fibrin
Fibrin Seals the Clot
Liver Produces Clotting Factors
Partial Thromboplastin Time (PTT)
Prothrombin Time (PT)
Convert Fibrinogen to Fibrin
Stabilizes the Platelet Plug
Hemolytic Uremic Syndrome (HUS)
Preceded by Acute Diarrheal Illness
Classic Triad of Symptoms
Microangiopathic Hemolytic Anemia (MAHA)
Von Willebrand Disease
Mixed platelet and coagulation disorder
Autosomal Dominant Condition Leading to Reduced vWF
Defect in platelet plug formation
Increased Bleeding Time
Factor VIII decreased
Normal platelet count
DDAVP (synthetic vasopressin)
Dark Green Leafy Vegetables
Synthesized by Intestinal Flora
Activated by Epoxide Reductase
Gamma Carboxylation of Glutamate
Activation of Clotting Factors II, VII, IX, X, Protein C and S
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