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Microbiology Viruses
Herpes Simplex Virus (HSV)
Characteristics
Enveloped
Double Stranded DNA
Linear
Signs and Symptoms
Type 1 HSV
Gingivostomatitis
Keratoconjunctivitis
Encephalitis of Temporal Lobes
Latent in Trigeminal Ganglia
Type 2 HSV
Genital Vesicles
Neonatal Herpes
TORCHES
Latent in Sacral Ganglia
Diagnosis
Tzanck Test
Multinucleated Giant Cells
Cowdry A Inclusions
Treatment
Acyclovir
2 mins
Varicella Zoster Virus (VZV)
Herpesvirus 3
Characteristics
Enveloped
Double Stranded DNA
Signs and Symptoms
Chickenpox
Pneumonia
Encephalitis
Trigeminal and Dorsal Root Ganglia
Shingles
Diagnosis
Tzanck Test
Multinucleated Giant Cells
Cowdry A Inclusion
Treatment
Acyclovir
2 mins
Epstein Barr Virus
Characteristics
Herpesvirus 4
Double Stranded DNA
Linear
Enveloped
Signs and Symptoms
Infectious Mononucleosis
Virus Attaches to CD21 in B Cells
Nasopharyngeal Carcinoma
Burkitt's Lymphoma
Hodgkin's Lymphoma
1 min
Epstein Barr Virus Mononucleosis
Mononucleosis
Fever
Hepatomegaly
Splenomegaly
Pharyngitis
Posterior Cervical Lymphadenopathy
Atypical Lymphocytes
Heterophile Antibodies
Rash Develops if treated with Ampicillin
Hodgkin's Lymphoma
2 mins
Cytomegalovirus (CMV)
Characteristics
Enveloped
Double Stranded DNA
Herpesvirus 5
Diagnosis
Non Heterophile Antibodies
Owl's eye inclusions
Signs and Symptoms
Congenital TORCH infection
Mononucleosis
Pneumonia
AIDS retinitis and esophagitis
Infection in transplant recipients
2 mins
Roseola
Exanthem
Herpesvirus 6
Enveloped
Double Stranded DNA
Linear
Signs and Symptoms
High Fevers Can Lead to Seizures
Diffuse Macular Rash After Fever
1 min
Hepatitis B Virus Characteristics
Hepadnavirus
Enveloped
Circular
Partially Double-stranded DNA
Has Reverse Transcriptase
IV Drug Use
Sex
Maternal Fetal Routes
3 Month Incubation Period
2 mins
Adenovirus
Characteristics
Non-enveloped
Icosahedral
Linear
Double Stranded DNA
Signs and Symptoms
Pharyngitis
Conjunctivitis
Fever
Summer Swimming
Day Care Centers
Acute Hemorrhagic Cystitis
Pneumonia
1 min
Parvovirus B19
Characteristics
DNA
Single Stranded
Linear
Smallest DNA virus
Non-enveloped
Signs and Symptoms
5th Disease
Slapped Cheek Rash in Children
Erythema Infectiosum
Hydrops Fetalis
RBC aplasia
Arthritis in Adults
Aplastic Crisis in Sickle Cell
Myocarditis
2 mins
Human Papillomavirus (HPV)
Characteristics
Non-enveloped
Circular
Double Stranded DNA
Disease
Warts 1, 2, 6, 11
Condyloma acuminata
Type 16, 18
Cervical Carcinoma
Penile Carcinoma
AIDS/Immunocompromised
Worsened by Smoking
Diagnosis
Koilocytic change in squamous epithelium
Pyknotic Nuclei Surrounded by Clear Halo
Treatment
Vaccine Available
4 mins
Polyomavirus
Characteristics
Non-enveloped
Double-stranded DNA
Circular
Disease
BK Virus
Kidney Damage
JC Virus
Progressive Multifocal Leukoencephalopathy (PML)
HIV/AIDS
Oligodendrocyte
Demyelination of CNS
4 mins
Pox Virus
Characteristics
Enveloped
Double-Stranded DNA
Linear
Non-Icosahedral
Signs and Symptoms
Smallpox
Cowpox
Molluscum Contagiosum
Umbilicated Flesh-Colored Domed Lesions
1 min
Rotavirus
Characteristics
Reovirus
Non-enveloped
Double-Stranded
RNA Virus
Linear
11 Segments
Triple Icosahedral Capsid
Most Common Cause of Diarrhea Worldwide
Villous Atrophy
Winter Months
Day Care Centers
Treatment
Oral Rehydration
2 mins
Picornavirus
Characteristics
Non-enveloped
RNA Virus
Icosahedral
Positive Sense
A large polypeptide cleaved by proteases
Viruses
Rhinovirus
Poliovirus
Coxsackievirus
Hepatitis A Virus
Echovirus
Aseptic meningitis
1 min
Rhinovirus
Picornavirus
Cause of Common Cold
More than 100 Serologic Types
Destroyed by Stomach Acid
32 secs
Yellow Fever Virus
Characteristics
Flavivirus
RNA Virus
Enveloped
Icosahedral
SS Positive Linear
Transmitted By Aedes Mosquitos
Monkey or Human Reservoir
Signs and Symptoms
High fever
Jaundice
Black vomitus
2 mins
Influenza Virus
Characteristics
RNA Virus
Orthomyxovirus
Enveloped
Negative Sense
8 Segments
Helical
Hemagglutinin for Viral Entry
Neuraminidase for Virion Release
Genetic Shift
Reassortment of genome to cause major change
Genetic Drift
Minor Antigenic Mutations
Considerations
Reye Syndrome with Aspirin Use
Guillain-Barre Syndrome
3 mins
Rubella
Characteristics
RNA Virus
Matonaviridae
Enveloped
Icosahedral
SS Positive Linear
Signs and Symptoms
German Measles or Three-Day Measles
Fever
Postauricular Tenderness
Lymphadenopathy
Truncal Rash
Arthritis
Congenital TORCH Infection
2 mins
Rubeola Virus
Characteristics
RNA Virus
Paramyxovirus
Signs and Symptoms
Measles
Rash Spreads From Head to Toe
Koplik Spots First
Red Spots with Blue-White Center on Buccal Mucosa
Cough
Coryza
Conjunctivitis
Subacute Sclerosing Panencephalitis
Giant Cell Pneumonia in Immunosuppressed Patients
Warthin-Finkeldey Multinucleated Giant Cells
Treatment
Vitamin A
3 mins
Mumps Virus
Characteristics
Paramyxovirus
Signs and Symptoms
Parotitis
Increased Serum Amylase
Orchitis
Oophoritis
Aseptic Meningitis
Pancreatitis
59 secs
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