sara Shared "Immune" - 33 Picmonics
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Immune
Anaphylaxis Intervention
- Intervention
- Assess Airway and Oxygen Needs
- Reassure Patient with Anxiety
- Supine Position
- Methylprednisolone (Solu-medrol)
- Epinephrine
- Diphenhydramine (Benadryl)
- Medical Alert Bracelet
2 mins
Cell-mediated Adaptive Immune Response
- Characteristics
- Macrophages and Dendritic Cells Present Antigens
- T Cell Develops Antigen Specificity
- Regulatory T Cells Suppress Response
- Memory T Cells Cause Faster Secondary Response
- Cytotoxic T Cells Lyse Infected Cells
- Infected Cells Present Antigen On Surface
2 mins
Humoral Adaptive Immunity
- Characteristics
- B Cell Binds Free Floating Antigen
- B Cell Presents Antigen to Helper T Cell
- Helper T Cells Help B Cells Develop Antigen Specificity
- Plasma B Cells Secrete Antibodies
- Memory B Cells Cause Faster Secondary Response
2 mins
Hypersensitivity Type I
- Previous Antigen Exposure
- Immediate Reaction
- IgE Cross-linking
- Presensitized Mast Cells
- Histamine Release
- Vasodilation
- Anaphylaxis
- Allergies
- Treatment
- Epinephrine
1 min
Hypersensitivity Type II
- Cytotoxic
- IgM or IgG antibody-mediated
- Membrane Attack Complex (MAC)
- Mechanism
- Opsonization
- Complement Activation
- NK Cells
- Testing
- Direct Coombs test
- Indirect Coombs Test
1 min
Hypersensitivity Type III
- Immune Complex
- Antigen-antibody (IgG) complex activates complement
- Neutrophils release lysozomal enzymes
- Examples
- Arthus Reaction
- Serum Sickness
- Systemic Lupus Erythematosus (SLE)
1 min
Hypersensitivity Type IV
- Delayed-Type Hypersensitivity
- T Cell Mediated
- Antibody Independant
- Macrophages Activated
- Examples
- Transplant Rejection
- PPD Skin Test
- Contact Dermatitis
1 min
Immune System Tissues
- Characteristics
- Bone Marrow
- B Cells and T Cells Formed
- B Cells Mature
- Thymus
- T Cells Tested For Self-Response
- T Cells Mature
- Lymph Nodes
- Mature B Cells and T Cells Monitor Lymph For Pathogens
- Spleen
- Mature B Cells and T Cells Monitor Blood For Pathogens
1 min
Inflammatory Response
- Pathogens Infect Tissue
- Mast Cells Release Histamine
- Histamine Dilates and Increases Capillary Permeability
- Macrophages Engulf Pathogens
- Macrophage Signals Cells With Cytokines
- Responding Neutrophils Cross Capillary Wall
- B And T Lymphocytes Arrive At Injury Site
2 mins
Innate Immunity Barriers
- Skin Protects Against Pathogens
- Normal Flora Outcompete Pathogens
- Lysozyme in Saliva, Tears, and Mucus
- Mucous Traps Pathogens
- Cilia Remove Mucus
- Acid and Digestive Enzymes in the Stomach Kill Pathogens
2 mins
Innate Immunity Cellular Response
- Characteristics
- Natural Killer Lymphocytes Attack Abnormal Cells
- Neutrophils in Blood
- Infected Cells Release Interferon
- Complement Proteins Lyse Pathogens/Infected Cells
- Dendritic Cells in Tissue
- Macrophages in Tissue
2 mins
Ataxia Telangiectasia
- Pathophysiology
- Autosomal Recessive
- ATM Gene
- Defect in DNA repair
- Signs & Symptoms
- Cerebellar defects
- Spider Angiomas
- Sensitive to Radiation
- Defective Tumor Suppressor Gene
- Increased risk of Cancer, Leukemias, and Lymphomas
- Increased AFP levels
- IgA deficiency
- Repeated sinopulmonary infections
2 mins
Bruton's Agammaglobulinemia
- Pathophysiology
- X-linked Recessive
- Defective Bruton Tyrosine Kinase
- Blocks B Cell Maturation
- Signs & Symptoms
- Decreased Immunoglobulins of All Classes
- Bacterial Infections After Six Months
- Maternal IgG Protects Before Six Months
2 mins
Bullous Pemphigoid
- Linear Deposits of IgG
- Affects Hemidesmosomes
- Epidermal Basement Membrane
- Tense Blisters on Skin
- Nikolsky Negative
- Contain Eosinophils
- Rarely Affect Oral Mucosa
2 mins
Chediak-Higashi Syndrome
- Pathophysiology
- Autosomal Recessive
- Defective Lysosomal Trafficking Regulator Gene (LYST)
- Defect In Microtubular Function
- Decrease In Phagocytosis
- Signs And Symptoms
- Recurrent Pyogenic Infections
- Staph Aureus And Streptococci
- Partial Albinism
- Peripheral Neuropathy
- Pancytopenia
- Diagnosis
- Giant Granules In Granulocytes And Platelets
2 mins
Chronic Granulomatous Disease
- Pathophysiology
- Most Commonly X-linked Recessive
- Defective NADPH Oxidase (Enzyme Complex)
- Decreased Hydrogen Peroxide
- Impaired Intracellular Killing in Phagocytes
- Signs and Symptoms
- Recurrent Purulent Skin and Lung Infections
- Catalase Positive Organisms
- Diagnosis
- Negative Nitroblue Tetrazolium Test
- DHR (Dihydrorhodamine) Flow Cytometry
- Treatment
- Antimicrobial Prophylaxis
- TMP-SMX
- Itraconazole
- Interferon-Gamma
3 mins
Chronic Mucocutaneous Candidiasis
- Mechanism and Characteristics
- T Cell Dysfunction
- Candida Albicans
- Signs and Symptoms
- Infections of Skin
- Infections of Mucous Membrane
- Susceptible to HPV Infections like Condyloma Acuminatum
42 secs
Common Variable Immunodeficiency
- Pathophysiology
- Defect in B Cell Maturation
- Decreased Plasma Cells
- Decreased Immunoglobulins
- Signs & Symptoms
- Sinopulmonary Infections
- Increased Risk of Autoimmune Disease
- Lymphoma
1 min
Graves' Disease Characteristics
- Women 20-40 years old
- Pathophysiology
- Anti-TSH Receptor Antibodies
- Symptoms
- Ophthalmopathy
- Exophthalmos
- Hyperthyroidism
- Goiter
- Pretibial Myxedema
1 min
Graves' Disease Labs and Treatment
- Labs
- Decreased TSH
- Increased T3
- Increased T4
- Radioactive Iodine Uptake (RAIU)
- Treatment
- Beta blocker
- Methimazole
- Radioiodine Ablation
1 min
