Carlos Shared "Carlos' Creator Contest Playlist" - 3 Picmonics

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Carlos' Creator Contest Playlist

Hyperchylomicronemia (Type I Familial Dyslipidemia)
INHERITANCE
Autosomal Recessive
PATHOGENESIS
Lipoprotein Lipase Deficiency (LPL)
Altered Apolipoprotein C-II (Apo C-II)
Lab Findings
Increased Chylomicrons
Increased Cholesterol
Increased Triglycerides
Symptoms/Findings
Pancreatitis
Hepatosplenomegaly
No Increased Risk for Atherosclerosis
Eruptive/Pruritic Xanthomas
Milky White Appearance of Blood When Drawn
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3 mins
Potter Sequence (Syndrome)
PATHOGENESIS
Oligohydramnios
clinical findings
Limb Deformities
Facial Anomalies
Pulmonary Hypoplasia Most Common Cause of Death
CAUSES
Autosomal Recessive Polycystic Kidney Disease (ARPKD)
Posterior Urethral Valves
Chronic Placental Insufficiency
Bilateral Renal Agenesis
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3 mins
Alzheimer Disease
Most common cause of dementia in elderly
Down syndrome patients have an Increased risk of developing Alzheimer
Associated with the following altered proteins:
EARLY ONSET (Familial)
APP (Chr 21)
Presenilin-1
Presenilin-2
LATE ONSET (sporadic)
ApoE4 in Chr 19: Increases risk of sporadic form
ApoE2 in Chr 19: Decreases risk of sporadic form (protective) due to Increase in Ach
Findings
Decrease Acetylcholine (ACh)
Widespread cortical atrophy (Narrowing of gyri and widening of sulci)
Senile plaques (Amyloid Beta plaques)
Neurofibrillary tangles
Can lead to intracranial hemorrhage
Hyperphosphorylated tau protein
The hippocampus is the area of the brain demostrating the greatest degree of atrophy. Hippocampal atrophy in MRI is highly suggestive of the diagnosis.
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