Amanda Shared "MMS Biochemistry II Exam 2" - 11 Picmonics
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MMS Biochemistry II Exam 2
Lipid Metabolism and Ketogenesis
- Lipid Metabolism
- Acetyl-CoA
- Biotin Cofactor
- Malonyl-CoA
- Fatty Acids
- Triglycerides
- Glycerol
- DHAP
- Acetoacetyl-CoA
- HMG-CoA
- HMG-CoA Reductase
- Mevalonate
- Cholesterol
- Ketogenesis
- Acetoacetate
- Beta-Hydroxybutyrate
4 mins
Oxidative Phosphorylation
- Inner Mitochondrial Membrane
- Electron Transport Chain
- Oxygen is Final Electron Acceptor
- Proton Pump
- Proton Motive Force
- ATP Synthase
- 1 NADH 3 ATP
- 1 FADH2 2 ATP
2 mins
Ezetimibe
- Indications
- Hyperlipidemia
- Mechanism of Action
- Cholesterol Absorption Blocker
- Decreases LDL
- Side Effects
- Diarrhea
- Increased LFT Values
57 secs
Fibrates
- Indications
- Hyperlipidemia
- Mechanism of Action
- Upregulate LPL
- Decreases Triglycerides
- Slight Increase in HDL
- Slight Decrease in LDL
- Side Effect
- Hepatotoxicity
- Cholesterol Gallstones
1 min
Statins
- Rhabdomyolysis
- Hepatotoxicity
- HMG-CoA reductase inhibitors
- Decrease LDL
- Decrease Triglycerides
- Increase HDL
2 mins
Atorvastatin (Lipitor)
- Characteristics
- -statin Suffix
- Mechanism
- HMG-CoA Reductase Inhibitors
- Indications
- High Cholesterol
- Side Effects
- Hepatotoxicity
- Rash
- Rhabdomyolysis
- Myopathy
- Considerations
- Monitor Liver Enzymes
- Administer at Bedtime
- Avoid Grapefruit
2 mins
Biotin (Vitamin B7)
- Mechanism
- Carboxylation reaction
- Pyruvate carboxylation to oxaloacetate
- Propionyl-CoA carboxylation to methylmalonyl-CoA
- Acetyl-CoA carboxylation to malonyl CoA
- Deficiency Causes
- Antibiotic Use
- Ingestion of Raw Eggs
- Signs & Symptoms
- Alopecia
- Dermatitis
- Enteritis
2 mins
Hypercholesterolemia Disease
- Risk Factors
- Diabetes
- Smoking
- Family History
- Hypertension
- HDL < 40
- Men Older than 45 Years of Age
- Women Older than 55 Years of Age
- Signs and Symptoms
- Atheromas
- Plaques in Blood Vessel Walls
- Tissue Ischemia
- Xanthomas
- Lipemia Retinalis
2 mins
Hypercholesterolemia Treatment
- Lifestyle Modifications (Diet, Exercise, Smoking Cessation)
- Statins
- Niacin
- Ezetimibe
- Fibrates
- Bile Acid Resins
- Screening
- Men greater or equal to 35 Years Old (20-35 if at increased risk)
- Women greater or equal to 45 Years Old (20-45 if at increased risk)
2 mins
Bile Acid Resins
- Indications
- Hyperlipidemia
- Mechanism of Action
- Bile Acid Reabsorption Prevented
- Slight Increase HDL/Triglycerides
- Decrease LDL
- Drugs
- Colestipol (Colestid)
- Cholestyramine
- Colesevelam
- Side Effects
- Cholesterol Gallstones
- Decreased Absorption of Fat-soluble Vitamins
- Patients Hate It
2 mins
Metformin
- Indications
- Diabetes Mellitus Type 2
- Polycystic Ovary Syndrome (PCOS)
- Mechanism of Action
- Decreased Gluconeogenesis
- Increased Insulin Sensitivity
- Side Effects
- Lactic Acidosis
- GI Distress
- Weight Loss
- B12 Deficiency
- Contraindication
- GFR < 30 ml/min
2 mins
