Yuri Kaylee Shared "Pharm" - 54 Picmonics
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Pharm
Cyclosporine (Sandimmune) Overview
- Mechanism
- Immunosuppressant
- Inhibits Calcineurin, Decreasing IL-2
- Indications
- Prevent Transplant Rejection
- Psoriasis
- Rheumatoid Arthritis
- Considerations
- Monitor Plasma Levels
- Avoid Grapefruit Juice
- Increased Risk of Lymphoma
2 mins
Cyclosporine (Sandimmune) Side Effects
- Side Effects
- Nephrotoxicity
- Hepatotoxicity
- Infection
- Hypertension
- Hirsutism
- Tremor
- Hyperkalemia
- Hypomagnesemia
- Gingival Hyperplasia
1 min
Dinoprostone and Misoprostol
- Mechanism
- Prostaglandins
- Indications
- Promote Cervical Ripening
- Prevent GI Ulcers
- Medical Abortion
- Side Effects
- Fetal Distress
- Hyperstimulation of Uterus
- Considerations
- Vaginal Insertion
- Give Before Induction of Labor
2 mins
Respiratory Acidosis
- Hypoventilation
- Increased PaCO2 > 45
- Barbiturates Depress Central Respiratory Center of Brain
- Opioids Depress Central Respiratory Center of the Brain
- Airway Obstruction
- Respiratory Muscle Weakness/Paralysis
3 mins
Opioids Overview
- Indications
- Pain
- Weaning
- Cough
- Diarrhea
- Mechanism of Action
- Agonists at Mu (μ), Kappa (Κ), and Delta (δ) Receptors
- Decrease Synaptic Transmission
- Side Effects
- Respiratory Depression
- Addiction
- Miosis
- Constipation
2 mins
Opioid Use Disorder and Withdrawal Assessment (Formerly Opioid Abuse and Withdrawal Assessment)
- Abuse Assessment
- Euphoria
- Miosis
- CNS Depression
- Abuse Withdrawal
- Yawning
- Gooseflesh
- Sweating
- Rhinorrhea
- Kicking Movements
- Consideration
- Naloxone
1 min
Opioid Antidote
- Antidote
- Naloxone
29 secs
Zanamivir (Relenza) and Oseltamivir (Tamiflu)
- Indications
- Influenza A and B
- Treatment and Prophylaxis
- Mechanism
- Inhibits Release of New Virus
- Inhibits Influenza Neuraminidase
1 min
Ribavirin
- Mechanism
- Hypermutation in RNA Viruses
- Inhibits Inosine Monophosphate Dehydrogenase
- Indications
- Hepatitis C
- Viral Hemorrhagic Fevers
- Respiratory Syncytial Virus (RSV)
- Side Effects
- Hemolytic Anemia
- Teratogen
1 min
Meperidine (Demerol)
- Mechanism
- Opioid Receptor Agonist
- Indications
- Moderate to Severe Pain
- Post Anesthesia Shivering
- Side Effects
- Tremors
- Constipation
- CNS Depression
- Sedation
- Considerations
- Short Term Administration
- Increased Risk Serotonin Syndrome
- Does NOT cause Miosis
- Renal Failure Increases Toxicity Risk
2 mins
Busulfan
- Indications
- CML
- Bone Marrow Ablation
- Mechanism
- Cross-Links DNA
- Side Effects
- Myelosuppression
- Pulmonary Fibrosis
- Hyperpigmentation
55 secs
Cyclophosphamide
- Mechanism
- Requires Bioactivation by Liver
- Cross-links DNA
- Guanine N7 Position
- Indications
- Autoimmune Disorders
- Leukemia
- Lymphoma
- Solid Tumors
- Side Effects
- Myelosuppression
- Hemorrhagic Cystitis
- Prevent with Mesna
3 mins
Cisplatin
- Indications
- Carcinomas
- Ovarian
- Bladder
- Lung
- Testicular
- Mechanism
- Cross-Links DNA
- Side Effects
- Ototoxicity
- Nephrotoxicity
- Treat with Amifostine and Chloride Diuresis
2 mins
Bleomycin
- Indications
- Testicular Cancer
- Hodgkin's Lymphoma
- Mechanism of Action
- Induces Free Radical Formation
- Breaks in DNA Strands
- Side Effects
- Pulmonary Fibrosis
- Skin Changes
- Mucositis
1 min
Doxorubicin (Adriamycin)
- Indications
- Solid Tumors
- Lymphomas and Leukemias
- Mechanism
- Free Radical Production
- Intercalates DNA
- Prevents Double Helix from Sealing
- Side Effect
- Cardiotoxicity
- Dexrazoxane Decreases Toxicity
1 min
Dactinomycin (Actinomycin D)
- Indications
- Wilms' Tumor
- Rhabdomyosarcoma
- Ewing's Sarcoma
- Gestational Trophoblastic Malignancy
- Mechanism
- Intercalates DNA
- Side Effect
- Myelosuppression
2 mins
Hydroxyurea
- Mechanism
- Inhibits Ribonucleotide Reductase
- Decreased DNA Synthesis
- S-phase Specific
- Indications
- Melanoma
- Chronic Myelogenous Leukemia (CML)
- Sickle Cell Disease
- Through Increased HbF (Fetal Hemoglobin)
- Side Effects
- Myelosuppression
- GI Distress
2 mins
Tamoxifen
- Mechanism of Action
- Selective Estrogen Receptor Modulator (SERM)
- Antagonist on Breast Tissue
- Indications
- ER-positive Breast Cancer
- Side Effects
- Decreased Risk of Osteoporosis
- Increased Risk of Endometrial Cancer
- Increased Risk of Venous Thromboembolism (VTE)
1 min
Methotrexate
- Indications
- Rheumatoid Arthritis
- Cancer
- Medical Abortion
- Mechanism
- Folic Acid Analog
- Inhibits Dihydrofolate Reductase
- Side Effects
- Pulmonary Fibrosis
- Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
- Macrocytic Anemia
- Hepatitis
- Teratogenic
- Mucositis
2 mins
Vincristine (Oncovin)
- Mechanism
- Vinca Alkaloid
- Inhibits Microtubules
- Indications
- Leukemias
- Lymphomas
- Side Effects
- Peripheral Neuropathy
- Paralytic Ileus
- Considerations
- Vesicant
2 mins
