Ashton Shared "Endocrine Pharmacology" - 39 Picmonics

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Endocrine Pharmacology

Glucocorticosteroids
Short Acting
Hydrocortisone
Cortisol
Intermediate acting
Prednisone (Glucocorticoids)
Methylprednisone (Solu-medrol)
Triamcinolone
Long Acting
Betamethasone
1 min
Prednisone (Glucocorticoids)
Mechanism
Glucocorticoid
Indications
Inflammatory Conditions
Organ Transplant Rejection
Side Effects
Cataracts and Glaucoma
Cushing's Syndrome
Osteoporosis
Immunosuppression
Hyperglycemia
Ulcers
Considerations
Adrenal Insufficiency
Taper Gradually
2 mins
Anti-Adrenal Medications
Desmolase (CYP11A1) Inhibitors
Ketoconazole
SFx: Hepatotoxicity
Metyrapone: also inhibits 11-Beta Hydroxylase
SFx: Hirsutism, Na/H2O Retention
Etomidate: also inhibits 11-Beta Hydroxylase
indicated for Anesthesia Induction & Sv. Cushing
SFx: Myoclonus
Adrenolytics
Mitotane
indicated for Adrenal Carcinoma
Mifepristone: Progresterone Antagonist
Azoles (Ketoconazole)
"-azole" suffix
Indications
Local and Less Serious Systemic Mycosis
Mechanism
Inhibits Ergosterol Synthesis
Inhibits P450
Side Effects
Liver Dysfunction
Inhibition of Testosterone Synthesis
1 min
Metyrapone
Blocks 11-Beta-Hydroxylase
Used to Treat Cushing Syndrome
Used to Diagnose Pituitary ACTH Reserve
K+ Sparing Diuretics
Indications
CHF and Hypertension
Hypokalemia
Hyperaldosteronism
Mechanism of Action
Collecting Tubule
Spironolactone
Competitive Aldosterone Receptor Antagonist
Amiloride and Triamterene
Block Na+ Channels
Side Effects
Hyperkalemia
Gynecomastia
2 mins
Spironolactone (Aldactone)
Mechanisms
Inhibition of Aldosterone
Potassium Retention
Indications
Hypertension
Edema
Heart Failure
Side Effects
Hyperkalemia
Endocrine Effects
Consideration
Avoid Potassium Supplements
2 mins
Growth Hormone
Somatropin
Mecasermin
Hypoglycemia
56 secs
Octreotide
Indications
Acute Variceal Bleeds
Pituitary Tumors
GH Secreting Tumors
Carcinoid Tumors
VIPoma
Mechanism
Somatostatin Analog
2 mins
Pegvisomant
GH antagonist
Acromegaly
Last Choice
Drugs Affecting Lactation
Dopamine Antagonists
Metoclopramide
Domperidone
Dopamine Agonists
Bromocriptine
Cabergoline
Combined Oral Contraceptives
Bromocriptine
Inhibit prolactin release
dopamine D2 receptor agonist
Partial Antagonist D1 receptor
small GH-secreting tumors
Hyperprolactinemia
Raynaud phenomenon
53 secs
Ergot Alkaloid: Bromocriptine
Mechanism of Action
D2 receptor AGONIST
D1 receptor ANTagonist
Contraindication
Coronary Heart Disease
Hypertension
Peripheral vascular disease
Side Effects
Nausea and Vomiting
Tardive Dyskinesia
Hallucinations
Indications
Migraine
Parkinson's Disease
52 secs
Desmopressin (DDAVP)
Synthetic vasopressin (ADH)
Binds V2 (renal and endothelial cells)
renal
Central Diabetes Insipidus
Nocturia
Bed Wetting (Nocturnal enuresis)
Heme
Stimulates Weibel-Palade bodies (endothelial cell)
Von Willbrand factor
Factor VIII
Von Willebrand Disease
Hemophilia A (factor 8 def)
Thrombocytopenia
Uremia (platelet aggregation)
Side Effects
Hyponatremia (fluid retention)
Nausea and Vomiting
Seizures
Confusion / Lethargy
Desmopressin
DDAVP (Desmopressin Acetate)
V1 Receptor
Tx: Prevents Thirst
Tx: Bed Wetting
Tx: Prevents Nocturia
Decrease Urine production in DI & Nocturnal
V2 preferred over V1 Receptor
Reduce Bleeding in vWF deficiency and Heamophilia A (VIII deficiency)
Fx: Pallor
Vasoconstriction
Nausea
Coronary
V1 Receptor
V2 Receptor Fx
V2 SIde Effects
Fx: Water intoxication
Hyponatremia
Endothelial Protein Release (vWF)
Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Pharmacologic Interventions
Diuretics
Hypertonic IV Fluids
Demeclocycline
Tolvaptan and Conivaptan
1 min
Vaptans
Conivaptan & Tolvaptan
MOA: Vasopressin Receptor ANTAGONIST
Conivaptan = V1a V2 ANTAGONIST
Tolvaptan V2 Receptor ANTAGONIST
Tx: Hyponatremia
Fx: Hypernatremia
Fx: Dry mouth
Fx: Liver damage & Hypotension
Fx: Nephrogenic Diabetes Insipidis
Fx: Osmotic Demylenation Syndrome
Fx: Increases Osmolality
Hypothyroidism Intervention
Medications
Levothyroxine (Synthroid)
Liothyronine (Cytomel)
Complication
Myxedema Coma
Nursing Considerations
Lifelong Replacement Hormone
Monitor Vital Signs
Fluids and Fiber
Low Calorie, Low Fat Diet
Medication Education
No Switching Brands
2 mins
Levothyroxine
Indications
Hypothyroidism
Myxedema Coma
Mechanism of Action
Isomer of thyroid hormone (T4)
T3 has higher potency
Side Effects
Hyperthyroid symptoms
56 secs
Hyperthyroidism Interventions
Drug Therapy
Propylthiouracil (PTU)
Methimazole (Tapazole)
Iodine
Beta Blockers
Other Therapies
Radioiodine Ablation
Thyroidectomy
Complications
Thyrotoxicosis
Post-Surgery Hypocalcemia
2 mins

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