Ashton Shared "Endocrine Pharmacology" - 39 Picmonics
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Endocrine Pharmacology
Glucocorticosteroids
- Short Acting
- Hydrocortisone
- Cortisol
- Intermediate acting
- Prednisone (Glucocorticoids)
- Methylprednisone (Solu-medrol)
- Triamcinolone
- Long Acting
- Betamethasone
1 min
Prednisone (Glucocorticoids)
- Mechanism
- Glucocorticoid
- Indications
- Inflammatory Conditions
- Organ Transplant Rejection
- Side Effects
- Cataracts and Glaucoma
- Cushing's Syndrome
- Osteoporosis
- Immunosuppression
- Hyperglycemia
- Ulcers
- Considerations
- Adrenal Insufficiency
- Taper Gradually
2 mins
Anti-Adrenal Medications
- Desmolase (CYP11A1) Inhibitors
- Ketoconazole
- SFx: Hepatotoxicity
- Metyrapone: also inhibits 11-Beta Hydroxylase
- SFx: Hirsutism, Na/H2O Retention
- Etomidate: also inhibits 11-Beta Hydroxylase
- indicated for Anesthesia Induction & Sv. Cushing
- SFx: Myoclonus
- Adrenolytics
- Mitotane
- indicated for Adrenal Carcinoma
- Mifepristone: Progresterone Antagonist
Azoles (Ketoconazole)
- "-azole" suffix
- Indications
- Local and Less Serious Systemic Mycosis
- Mechanism
- Inhibits Ergosterol Synthesis
- Inhibits P450
- Side Effects
- Liver Dysfunction
- Inhibition of Testosterone Synthesis
1 min
Metyrapone
- Blocks 11-Beta-Hydroxylase
- Used to Treat Cushing Syndrome
- Used to Diagnose Pituitary ACTH Reserve
K+ Sparing Diuretics
- Indications
- CHF and Hypertension
- Hypokalemia
- Hyperaldosteronism
- Mechanism of Action
- Collecting Tubule
- Spironolactone
- Competitive Aldosterone Receptor Antagonist
- Amiloride and Triamterene
- Block Na+ Channels
- Side Effects
- Hyperkalemia
- Gynecomastia
2 mins
Spironolactone (Aldactone)
- Mechanisms
- Inhibition of Aldosterone
- Potassium Retention
- Indications
- Hypertension
- Edema
- Heart Failure
- Side Effects
- Hyperkalemia
- Endocrine Effects
- Consideration
- Avoid Potassium Supplements
2 mins
Growth Hormone
- Somatropin
- Mecasermin
- Hypoglycemia
57 secs
Octreotide
- Indications
- Acute Variceal Bleeds
- Pituitary Tumors
- GH Secreting Tumors
- Carcinoid Tumors
- VIPoma
- Mechanism
- Somatostatin Analog
2 mins
Pegvisomant
- GH antagonist
- Acromegaly
- Last Choice
Drugs Affecting Lactation
- Dopamine Antagonists
- Metoclopramide
- Domperidone
- Dopamine Agonists
- Bromocriptine
- Cabergoline
- Combined Oral Contraceptives
Bromocriptine
- Inhibit prolactin release
- dopamine D2 receptor agonist
- Partial Antagonist D1 receptor
- small GH-secreting tumors
- Hyperprolactinemia
- Raynaud phenomenon
53 secs
Ergot Alkaloid: Bromocriptine
- Mechanism of Action
- D2 receptor AGONIST
- D1 receptor ANTagonist
- Contraindication
- Coronary Heart Disease
- Hypertension
- Peripheral vascular disease
- Side Effects
- Nausea and Vomiting
- Tardive Dyskinesia
- Hallucinations
- Indications
- Migraine
- Parkinson's Disease
52 secs
Desmopressin (DDAVP)
- Synthetic vasopressin (ADH)
- Binds V2 (renal and endothelial cells)
- renal
- Central Diabetes Insipidus
- Nocturia
- Bed Wetting (Nocturnal enuresis)
- Heme
- Stimulates Weibel-Palade bodies (endothelial cell)
- Von Willbrand factor
- Factor VIII
- Von Willebrand Disease
- Hemophilia A (factor 8 def)
- Thrombocytopenia
- Uremia (platelet aggregation)
- Side Effects
- Hyponatremia (fluid retention)
- Nausea and Vomiting
- Seizures
- Confusion / Lethargy
Desmopressin
- DDAVP (Desmopressin Acetate)
- V1 Receptor
- Tx: Prevents Thirst
- Tx: Bed Wetting
- Tx: Prevents Nocturia
- Decrease Urine production in DI & Nocturnal
- V2 preferred over V1 Receptor
- Reduce Bleeding in vWF deficiency and Heamophilia A (VIII deficiency)
- Fx: Pallor
- Vasoconstriction
- Nausea
- Coronary
- V1 Receptor
- V2 Receptor Fx
- V2 SIde Effects
- Fx: Water intoxication
- Hyponatremia
- Endothelial Protein Release (vWF)
Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Pharmacologic Interventions
- Diuretics
- Hypertonic IV Fluids
- Demeclocycline
- Tolvaptan and Conivaptan
1 min
Vaptans
- Conivaptan & Tolvaptan
- MOA: Vasopressin Receptor ANTAGONIST
- Conivaptan = V1a V2 ANTAGONIST
- Tolvaptan V2 Receptor ANTAGONIST
- Tx: Hyponatremia
- Fx: Hypernatremia
- Fx: Dry mouth
- Fx: Liver damage & Hypotension
- Fx: Nephrogenic Diabetes Insipidis
- Fx: Osmotic Demylenation Syndrome
- Fx: Increases Osmolality
Hypothyroidism Intervention
- Medications
- Levothyroxine (Synthroid)
- Liothyronine (Cytomel)
- Complication
- Myxedema Coma
- Nursing Considerations
- Lifelong Replacement Hormone
- Monitor Vital Signs
- Fluids and Fiber
- Low Calorie, Low Fat Diet
- Medication Education
- No Switching Brands
2 mins
Levothyroxine
- Indications
- Hypothyroidism
- Myxedema Coma
- Mechanism of Action
- Isomer of Thyroid Hormone (T4)
- T3 has Higher Potency
- Side Effects
- Hyperthyroid Symptoms
57 secs
Hyperthyroidism Interventions
- Drug Therapy
- Propylthiouracil (PTU)
- Methimazole (Tapazole)
- Iodine
- Beta Blockers
- Other Therapies
- Radioiodine Ablation
- Thyroidectomy
- Complications
- Thyrotoxicosis
- Post-Surgery Hypocalcemia
2 mins
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