Alyssa Shared "Share w Herb (Antirejection Medications)" - 9 Picmonics

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Share w Herb (Antirejection Medications)

Prednisone (Glucocorticoids)
Mechanism
Glucocorticoid
Indications
Inflammatory Conditions
Organ Transplant Rejection
Side Effects
Cataracts and Glaucoma
Cushing's Syndrome
Osteoporosis
Immunosuppression
Hyperglycemia
Ulcers
Considerations
Adrenal Insufficiency
Taper Gradually
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2 mins
Cyclosporine (Sandimmune) Overview
Mechanism
Immunosuppressant
Inhibits Calcineurin, Decreasing IL-2
Indications
Prevent Transplant Rejection
Psoriasis
Rheumatoid Arthritis
Considerations
Monitor Plasma Levels
Avoid Grapefruit Juice
Increased Risk of Lymphoma
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2 mins
Tacrolimus (Prograf) Overview
Mechanisms
Immunosuppressant
Inhibits Calcineurin, Decreasing IL-2
Indications
Transplant Rejection
Atopic Dermatitis
Considerations
Increased Lymphoma Risk
Avoid Grapefruit Juice
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1 min
Tacrolimus (Prograf) Side Effects
Nephrotoxicity
Neurotoxicity
GI Distress
Infection
Hypertension
Hyperkalemia
Hyperglycemia
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1 min
Mycophenolate Mofetil
reversible inhibitor of IMP dehydrogenase
ppx of transplant rejection
long half life
leukopenia
risk for infections
pure rbc aplasia
pregnancy loss
Vomiting
TX lupus nephritis
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Sirolimus, Everolimus
mTOR inhibitor
Bind to FKBP
PREVENT response to IL-2
metabolized by liver
Hyperlipidemia
NO nephrotoxicity
Everolimus has shorter half life
Sirolimus has longer half life
used in transplant rejection ppx when pt has calcineurine inhibitor toxicity or intolerance
siroll-mus
fkbp
T cell inhibitor
Indications: Rheumatoid Arthritis and Psoriasis
Thrombocytopenia
hypertension
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Basiliximab, Daclizumab
Basiliximab
block IL-2 activation of T cells
renal transplant rejection ppx
Edema
Hypertension
Tremors
Hypersensitivity rxn
Daclizumab
does not risk increase of infection
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Thymoglobulin/Antithymocyte globin
anti-rabbit that targets T lymphocytes
Tx of rejection
chills, fever
leukopenia
Infection
lymphopenia
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Hypochromic Microcytic Anemia Drugs
Boosts Fetal Hb
Clincal Uses: Sickle Cell and Beta Thalassemia
fever/chills
lower back pain
painful urination 
Reticulocytes within few days, increase in Hb in 2 weeks
Iron replacement treatment poor iron absorption due to celiac disease, whipple disease, rheumatoid arthritis, and SLE
oral iron should not be enteric coated or extended release
meat, fish, poultry = best dietary sources of iron
perenteral iron bypasses site of bodys iron regulation
Side effects: constipation, heartburn, vomiting, diarrhea, dark stools, anorexia, nausea
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