Alyssa Shared "Share w Herb (Antirejection Medications)" - 9 Picmonics
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Share w Herb (Antirejection Medications)
Prednisone (Glucocorticoids)
- Mechanism
- Glucocorticoid
- Indications
- Inflammatory Conditions
- Organ Transplant Rejection
- Side Effects
- Cataracts and Glaucoma
- Cushing's Syndrome
- Osteoporosis
- Immunosuppression
- Hyperglycemia
- Ulcers
- Considerations
- Adrenal Insufficiency
- Taper Gradually
2 mins
Cyclosporine (Sandimmune) Overview
- Mechanism
- Immunosuppressant
- Inhibits Calcineurin, Decreasing IL-2
- Indications
- Prevent Transplant Rejection
- Psoriasis
- Rheumatoid Arthritis
- Considerations
- Monitor Plasma Levels
- Avoid Grapefruit Juice
- Increased Risk of Lymphoma
2 mins
Tacrolimus (Prograf) Overview
- Mechanisms
- Immunosuppressant
- Inhibits Calcineurin, Decreasing IL-2
- Indications
- Transplant Rejection
- Atopic Dermatitis
- Considerations
- Increased Lymphoma Risk
- Avoid Grapefruit Juice
1 min
Tacrolimus (Prograf) Side Effects
- Nephrotoxicity
- Neurotoxicity
- GI Distress
- Infection
- Hypertension
- Hyperkalemia
- Hyperglycemia
1 min
Mycophenolate Mofetil
- reversible inhibitor of IMP dehydrogenase
- ppx of transplant rejection
- long half life
- leukopenia
- risk for infections
- pure rbc aplasia
- pregnancy loss
- Vomiting
- TX lupus nephritis
Sirolimus, Everolimus
- mTOR inhibitor
- Bind to FKBP
- PREVENT response to IL-2
- metabolized by liver
- Hyperlipidemia
- NO nephrotoxicity
- Everolimus has shorter half life
- Sirolimus has longer half life
- used in transplant rejection ppx when pt has calcineurine inhibitor toxicity or intolerance
- siroll-mus
- fkbp
- T cell inhibitor
- Indications: Rheumatoid Arthritis and Psoriasis
- Thrombocytopenia
- hypertension
Basiliximab, Daclizumab
- Basiliximab
- block IL-2 activation of T cells
- renal transplant rejection ppx
- Edema
- Hypertension
- Tremors
- Hypersensitivity rxn
- Daclizumab
- does not risk increase of infection
Thymoglobulin/Antithymocyte globin
- anti-rabbit that targets T lymphocytes
- Tx of rejection
- chills, fever
- leukopenia
- Infection
- lymphopenia
Hypochromic Microcytic Anemia Drugs
- Boosts Fetal Hb
- Clincal Uses: Sickle Cell and Beta Thalassemia
- fever/chills
- lower back pain
- painful urination
- Reticulocytes within few days, increase in Hb in 2 weeks
- Iron replacement treatment poor iron absorption due to celiac disease, whipple disease, rheumatoid arthritis, and SLE
- oral iron should not be enteric coated or extended release
- meat, fish, poultry = best dietary sources of iron
- perenteral iron bypasses site of bodys iron regulation
- Side effects: constipation, heartburn, vomiting, diarrhea, dark stools, anorexia, nausea
