Wayne Shared "Pathology Bliss 6/9/2024" - 51 Picmonics
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Pathology Bliss 6/9/2024
Severe Sepsis and Septic Shock Assessment
- Microthrombi
- DIC
- Decreased Oxygen Saturation
- Decreased WBC
- Oliguria
- High Output Heart Failure
- Multiple Organ Failure
2 mins
Disseminated Intravascular Coagulation (DIC)
- Pathophysiology
- Bleeding State
- Activation of Clotting Factors
- Deficiency of Clotting Factors
- Causes
- Sepsis
- Trauma
- Obstetric Complications
- Acute Pancreatitis
- Malignancy
- Nephrotic Syndrome
- Transfusion
2 mins
Common Causes of Sepsis
- Staphylococcus aureus
- Staphylococcus epidermidis
- Streptococcus bovis
- Gram Negatives
- Enterococci
- Listeria
- Neisseria gonorrhoeae
- Neisseria meningitidis
2 mins
Sepsis Assessment
- Signs and Symptoms
- Systemic Infectious Process
- Fever
- Hypotension
- Change in LOC
- Increased WBC
- Shift to the Left
- Tachycardia
- Tachypnea
- Hyperglycemia
- Edema
2 mins
Types of Shock
- Hypovolemic
- Depleted Volume
- Cardiogenic
- Pump Failure
- Obstructive
- Indirect Pump Failure
- Distributive
- Lost Vascular Tone
- Neurogenic
- Anaphylactic
- Septic
2 mins
Pulmonary Embolism Causes
- Causes
- FAT BAT Mnemonic
- Fat
- Air
- Deep Vein Thrombosis (DVT)
- Bacteria
- Amniotic Fluid
- Tumor
- Risk Factors
- Hypercoagulable
- Central Venous Lines
- Immobilized
1 min
Wells' Criteria for Pulmonary Embolism
- Scoring
- Clinical Symptoms of DVT (+3)
- Pulmonary Embolism Most Likely Diagnosis (+3)
- Tachycardia (+1.5)
- Immobilization > 3 Days (+1.5)
- Previous DVT or PE (+1.5)
- Hemoptysis (+1)
- Malignancy (+1)
- Probability
- > 6 = High
- 2-6 = Moderate
- < 2 = Low
3 mins
Pulmonary Embolism Presentation and Diagnosis
- Presentation
- Sudden onset Shortness of Breath (S.O.B.)
- Tachypnea
- Pleuritic Chest Pain
- Hemoptysis
- Hypoxemia
- Sudden Death
- Diagnosis
- Gold Standard: CT Pulmonary Angiography
- X-Ray
- D-Dimer
- V/Q Scan
1 min
Amyloidosis
- Etiologies
- Primary
- Multiple Myeloma
- Secondary
- Tuberculosis (TB)
- Rheumatoid Arthritis
- Pathology
- Congo Red Stain
- Apple Green Birefringence
- Complications
- Nephrotic Syndrome
2 mins
Multiple Sclerosis Features and Mechanisms
- Features
- More Common in Women
- Presents in 20's and 30's
- Northern Europeans
- Mechanism
- Unknown mechanism, genetic factor
- HLA-DRB1
- Autoimmune Demyelination of CNS
- White Matter of Brain and Spinal Cord
- T Cell Mediated Inflammation
2 mins
Diffuse Large B Cell Lymphoma
- Epidemiology
- Most Common Non-Hodgkin’s Lymphoma
- Usually in Older Adults
- 20% in Children
- Features
- May be Mature T Cell in Origin
- Derives from Germinal Center
- GI Tract and Brain
2 mins
Familial Mediterranean Fever (FMF)
- Etiology
- Most Common Inherited Fever Syndrome
- Mediterranean Populations
- Cause/Mechanism
- Autosomal Recessive
- Clinical Symptoms
- Recurring Fever
- Abdominal Pain
- Serositis
- Arthralgia
- Chest Pain
- Scrotal Pain
- Mistaken for Appendicitis
- Complication
- AA Amyloidosis
- Treatment
- Colchicine
2 mins
Chronic Myelogenous Leukemia (CML)
- Pathophysiology
- BCR-ABL
- 9;22 Translocation
- Philadelphia Chromosome
- Signs & Symptoms
- Tyrosine Kinase
- Low Alkaline Phosphatase
- Splenomegaly
- Considerations
- Blast Crisis
- Age 30 to 90 Years
- Responds to Imatinib
3 mins
Imatinib (Gleevec)
- Indications
- Chronic Myelogenous Leukemia (CML)
- Inhibitor of BCR-ABL Tyrosine Kinase
- Caused by Philadelphia Chromosome
- GI Stromal Tumors
- Inhibitor of C-kit Tyrosine Kinase
- Toxicity
- Fluid Retention
1 min
Burkitt's Lymphoma
- Adolescents or young adults
- C-myc gene moves next to heavy chain Ig gene
- T 8;14
- Starry sky appearance
- Sheets of lymphocytes with interspersed macrophages
- Jaw lesion in endemic (African) form
- Pelvis or abdomen in non endemic form (American form)
- Associated with EBV
2 mins
Neoplastic Colonic Polyps
- Characteristic
- Malignant
- Types
- Adenomatous Polyps
- APC and KRAS Mutation
- Villous Type is more Malignant
- Serrated Polyps
- BRAF Mutation
- Saw-Tooth Pattern
2 mins
Trastuzumab
- Indications
- HER-2+ Breast Cancer
- Stomach Cancer
- Mechanism
- Monoclonal Antibody Against HER-2
- Inhibition of Cellular Signaling
- Cytotoxicity
- Side effects
- Cardiotoxicity
1 min
Breast Cancer Diagnosis
- Mammography
- Ultrasound
- MRI for High Risk Patients
- Confirmed with Biopsy
- Considerations
- Lymph Node Involvement
- Receptor Positivity
- Estrogen and Progesterone Receptors
- HER-2
2 mins
MEN 2A (Multiple Endocrine Neoplasia)
- Pathophysiology
- Autosomal Dominant
- RET Gene
- Signs and Symptoms
- Medullary Thyroid carcinoma
- Calcitonin
- Parathyroid
- Pheochromocytoma
45 secs
MEN 2B (Multiple Endocrine Neoplasia)
- Pathophysiology
- RET Gene
- Autosomal Dominant
- Signs and Symptoms
- Medullary Thyroid Carcinoma
- Pheochromocytoma
- Mucosal Neuromas
- Marfanoid Body Habitus
2 mins
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